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Allelic loss on chromosome 6Q in primary prostate cancer.

Publication ,  Journal Article
Srikantan, V; Sesterhenn, IA; Davis, L; Hankins, GR; Avallone, FA; Livezey, JR; Connelly, R; Mostofi, FK; McLeod, DG; Moul, JW; Srivastava, S ...
Published in: Int J Cancer
June 21, 1999

Molecular genetic analyses of human prostate cancer (CaP) has revealed frequent loss of specific chromosome regions suggesting the presence of putative tumor suppressor gene(s) (TSG) on these chromosome loci whose inactivation may play a role in prostate tumorigenesis. To understand the role of 6q alterations in CaP, we have undertaken a comprehensive analysis of proximal 6q. Genomic DNA from tumor and normal prostate tissues from radical prostatectomy specimens of 38 patients were analyzed by polymerase chain reaction (PCR) for 13 polymorphic microsatellite loci on 6q. Allelic losses of 1 or more polymorphic loci were detected in 11 of 38 patients (29%). Six of 11 tumors showing any 6q deletion were found to have allelic losses at D6S1056 and D6S300 loci. Our results revealed a 1.5 megabase interval between D6S1056 and D6S300 at 6q16.3-21 as the minimal region of deletion, which may contain the putative TSG involved in prostate tumorigenesis. One of the tumor samples demonstrated homozygous deletion at a distal location D6S314 (6q23-24), suggesting another locus potentially associated with CaP. Although the relationship of 6q loss of heterozygosity (LOH) with various clinico-pathologic variables, i.e., cancer recurrence or pathologic stage, did not reveal a statistically significant association, the risk for 6q LOH to non-organ confined (pT3) disease was 5-fold higher than for organ confined disease.

Duke Scholars

Published In

Int J Cancer

DOI

ISSN

0020-7136

Publication Date

June 21, 1999

Volume

84

Issue

3

Start / End Page

331 / 335

Location

United States

Related Subject Headings

  • Prostatic Neoplasms
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Loss of Heterozygosity
  • Humans
  • Genes, Tumor Suppressor
  • Chromosomes, Human, Pair 6
  • Aged
  • Adult
 

Citation

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Srikantan, V., Sesterhenn, I. A., Davis, L., Hankins, G. R., Avallone, F. A., Livezey, J. R., … Srivastava, S. (1999). Allelic loss on chromosome 6Q in primary prostate cancer. Int J Cancer, 84(3), 331–335. https://doi.org/10.1002/(sici)1097-0215(19990621)84:3<331::aid-ijc23>3.0.co;2-j
Srikantan, V., I. A. Sesterhenn, L. Davis, G. R. Hankins, F. A. Avallone, J. R. Livezey, R. Connelly, et al. “Allelic loss on chromosome 6Q in primary prostate cancer.Int J Cancer 84, no. 3 (June 21, 1999): 331–35. https://doi.org/10.1002/(sici)1097-0215(19990621)84:3<331::aid-ijc23>3.0.co;2-j.
Srikantan V, Sesterhenn IA, Davis L, Hankins GR, Avallone FA, Livezey JR, et al. Allelic loss on chromosome 6Q in primary prostate cancer. Int J Cancer. 1999 Jun 21;84(3):331–5.
Srikantan, V., et al. “Allelic loss on chromosome 6Q in primary prostate cancer.Int J Cancer, vol. 84, no. 3, June 1999, pp. 331–35. Pubmed, doi:10.1002/(sici)1097-0215(19990621)84:3<331::aid-ijc23>3.0.co;2-j.
Srikantan V, Sesterhenn IA, Davis L, Hankins GR, Avallone FA, Livezey JR, Connelly R, Mostofi FK, McLeod DG, Moul JW, Chandrasekharappa SC, Srivastava S. Allelic loss on chromosome 6Q in primary prostate cancer. Int J Cancer. 1999 Jun 21;84(3):331–335.
Journal cover image

Published In

Int J Cancer

DOI

ISSN

0020-7136

Publication Date

June 21, 1999

Volume

84

Issue

3

Start / End Page

331 / 335

Location

United States

Related Subject Headings

  • Prostatic Neoplasms
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Loss of Heterozygosity
  • Humans
  • Genes, Tumor Suppressor
  • Chromosomes, Human, Pair 6
  • Aged
  • Adult