Perineal seeding of prostate cancer as the only evidence of clinical recurrence 14 years after needle biopsy and radical prostatectomy: molecular correlation.

Journal Article (Journal Article)

Perineal needle tract seeding of prostate cancer is an unusual complication of perineal prostate biopsy. We report a case with the longest known interval from biopsy to perineal recurrence--14 years. The prostate-specific antigen did not become detectable until 12 years after biopsy and no other metastases were apparent, suggesting that the patient's perineal disease was an isolated recurrence. Immunohistochemical staining of the perineal recurrence and the original biopsy and prostate for the p53 tumor suppressor gene and bcl-2 oncogene proteins revealed rare/absent p53 expression but marked increased bcl-2 expression. This unusual molecular pedigree may help to explain this rare clinical scenario.

Full Text

Duke Authors

Cited Authors

  • Moul, JW; Bauer, JJ; Srivastava, S; Colon, E; Ho, CK; Sesterhenn, IA; McLeod, DG

Published Date

  • January 1998

Published In

Volume / Issue

  • 51 / 1

Start / End Page

  • 158 - 160

PubMed ID

  • 9457312

International Standard Serial Number (ISSN)

  • 0090-4295

Digital Object Identifier (DOI)

  • 10.1016/s0090-4295(97)00487-1


  • eng

Conference Location

  • United States