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p63 expression profile in normal and malignant prostate epithelial cells.

Publication ,  Journal Article
Davis, LD; Zhang, W; Merseburger, A; Young, D; Xu, L; Rhim, JS; Moul, JW; Srivastava, S; Sesterhenn, IA
Published in: Anticancer Res
2002

p63 expression was evaluated in a tissue microarray of prostate tissues including benign glands, prostatic intraepithelial neoplasia and prostatic carcinoma. Immunostaining with anti-p63 antibody was restricted to basal cell nuclei. Detectable p63 was found in immortalized and early passage cell cultures, but not in senescent cultures or metastatic tumor-derived cell lines. The selective presence of p63 in basal cells of the prostate suggests that p63 can be used as a marker of basal cells and in vitro typing cell cultures of prostate cancer (CaP). The basal cell association underscores its critical functions in the biology of basal cells.

Duke Scholars

Published In

Anticancer Res

ISSN

0250-7005

Publication Date

2002

Volume

22

Issue

6C

Start / End Page

3819 / 3825

Location

Greece

Related Subject Headings

  • Tumor Suppressor Proteins
  • Tumor Cells, Cultured
  • Transcription Factors
  • Trans-Activators
  • Reverse Transcriptase Polymerase Chain Reaction
  • Prostatic Neoplasms
  • Phosphoproteins
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Middle Aged
 

Citation

APA
Chicago
ICMJE
MLA
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Davis, L. D., Zhang, W., Merseburger, A., Young, D., Xu, L., Rhim, J. S., … Sesterhenn, I. A. (2002). p63 expression profile in normal and malignant prostate epithelial cells. Anticancer Res, 22(6C), 3819–3825.
Davis, Leland D., Wei Zhang, Axel Merseburger, Denise Young, Linda Xu, Johng S. Rhim, Judd W. Moul, Shiv Srivastava, and Isabell A. Sesterhenn. “p63 expression profile in normal and malignant prostate epithelial cells.Anticancer Res 22, no. 6C (2002): 3819–25.
Davis LD, Zhang W, Merseburger A, Young D, Xu L, Rhim JS, et al. p63 expression profile in normal and malignant prostate epithelial cells. Anticancer Res. 2002;22(6C):3819–25.
Davis, Leland D., et al. “p63 expression profile in normal and malignant prostate epithelial cells.Anticancer Res, vol. 22, no. 6C, 2002, pp. 3819–25.
Davis LD, Zhang W, Merseburger A, Young D, Xu L, Rhim JS, Moul JW, Srivastava S, Sesterhenn IA. p63 expression profile in normal and malignant prostate epithelial cells. Anticancer Res. 2002;22(6C):3819–3825.

Published In

Anticancer Res

ISSN

0250-7005

Publication Date

2002

Volume

22

Issue

6C

Start / End Page

3819 / 3825

Location

Greece

Related Subject Headings

  • Tumor Suppressor Proteins
  • Tumor Cells, Cultured
  • Transcription Factors
  • Trans-Activators
  • Reverse Transcriptase Polymerase Chain Reaction
  • Prostatic Neoplasms
  • Phosphoproteins
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Middle Aged