p63 expression profile in normal and malignant prostate epithelial cells.
Journal Article (Journal Article)
p63 expression was evaluated in a tissue microarray of prostate tissues including benign glands, prostatic intraepithelial neoplasia and prostatic carcinoma. Immunostaining with anti-p63 antibody was restricted to basal cell nuclei. Detectable p63 was found in immortalized and early passage cell cultures, but not in senescent cultures or metastatic tumor-derived cell lines. The selective presence of p63 in basal cells of the prostate suggests that p63 can be used as a marker of basal cells and in vitro typing cell cultures of prostate cancer (CaP). The basal cell association underscores its critical functions in the biology of basal cells.
- Davis, LD; Zhang, W; Merseburger, A; Young, D; Xu, L; Rhim, JS; Moul, JW; Srivastava, S; Sesterhenn, IA
Volume / Issue
- 22 / 6C
Start / End Page
- 3819 - 3825
International Standard Serial Number (ISSN)