p63 expression profile in normal and malignant prostate epithelial cells.

Journal Article (Journal Article)

p63 expression was evaluated in a tissue microarray of prostate tissues including benign glands, prostatic intraepithelial neoplasia and prostatic carcinoma. Immunostaining with anti-p63 antibody was restricted to basal cell nuclei. Detectable p63 was found in immortalized and early passage cell cultures, but not in senescent cultures or metastatic tumor-derived cell lines. The selective presence of p63 in basal cells of the prostate suggests that p63 can be used as a marker of basal cells and in vitro typing cell cultures of prostate cancer (CaP). The basal cell association underscores its critical functions in the biology of basal cells.

Full Text

Duke Authors

Cited Authors

  • Davis, LD; Zhang, W; Merseburger, A; Young, D; Xu, L; Rhim, JS; Moul, JW; Srivastava, S; Sesterhenn, IA

Published Date

  • 2002

Published In

Volume / Issue

  • 22 / 6C

Start / End Page

  • 3819 - 3825

PubMed ID

  • 12553000

International Standard Serial Number (ISSN)

  • 0250-7005


  • eng

Conference Location

  • Greece