Hormonal therapy options for biochemical recurrence of prostate cancer after local therapy.
Recurrence after local prostate cancer treatment detectable only by a rise in serum prostate specific antigen (PSA) is a very common problem facing clinicians. Given that the majority of these men are relatively young and otherwise healthy, treatment of PSA-only recurrence requires approaches that not only improve survival but also preserve quality of life. For radical prostatectomy patients, a PSA-only recurrence is broadly defined as persistent or rising PSA in the postoperative period. For radiation-treated patients, the 1997 American Society for Therapeutic Radiology and Oncology guidelines specify three consecutive elevations of PSA after the post-treatment nadir PSA is achieved. Traditional hormonal therapy is the mainstay of systemic treatment for PSA-only recurrence, although nontraditional approaches such as intermittent and oral-only hormonal therapy are under study.
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Related Subject Headings
- Urology & Nephrology
- Treatment Failure
- Prostatic Neoplasms
- Prostate-Specific Antigen
- Neoplasm Recurrence, Local
- Male
- Humans
- Drug Administration Schedule
- Disease Progression
- Antineoplastic Combined Chemotherapy Protocols
Citation
Published In
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Urology & Nephrology
- Treatment Failure
- Prostatic Neoplasms
- Prostate-Specific Antigen
- Neoplasm Recurrence, Local
- Male
- Humans
- Drug Administration Schedule
- Disease Progression
- Antineoplastic Combined Chemotherapy Protocols