Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients.

Journal Article (Journal Article)

PCGEM1 is a novel, highly prostate tissue-specific, androgen-regulated gene. Here, we demonstrate that PCGEM1 expression is significantly higher in prostate cancer (CaP) cells of African-American men than in Caucasian-American men (P=0.0002). Further, increased PCGEM1 expression associates with normal prostate epithelial cells of CaP patients with a family history of CaP (P=0.0400). PCGEM1 overexpression in LNCaP and in NIH3T3 cells promotes cell proliferation and a dramatic increase in colony formation, suggesting a biological role of PCGEM1 in cell growth regulation. Taken together, the cell proliferation/colony formation-promoting functions of PCGEM1 and the association of its increased expression with high-risk CaP patients suggest the potential roles of PCGEM1 in CaP onset/progression, especially in these high-risk groups.

Full Text

Duke Authors

Cited Authors

  • Petrovics, G; Zhang, W; Makarem, M; Street, JP; Connelly, R; Sun, L; Sesterhenn, IA; Srikantan, V; Moul, JW; Srivastava, S

Published Date

  • January 15, 2004

Published In

Volume / Issue

  • 23 / 2

Start / End Page

  • 605 - 611

PubMed ID

  • 14724589

International Standard Serial Number (ISSN)

  • 0950-9232

Digital Object Identifier (DOI)

  • 10.1038/sj.onc.1207069


  • eng

Conference Location

  • England