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Optimized prostate biopsy via a statistical atlas of cancer spatial distribution.

Publication ,  Journal Article
Shen, D; Lao, Z; Zeng, J; Zhang, W; Sesterhenn, IA; Sun, L; Moul, JW; Herskovits, EH; Fichtinger, G; Davatzikos, C
Published in: Med Image Anal
June 2004
Published version (DOI) Link to item

A methodology is presented for constructing a statistical atlas of spatial distribution of prostate cancer from a large patient cohort, and it is used for optimizing needle biopsy. An adaptive-focus deformable model is used for the spatial normalization and registration of 100 prostate histological samples, which were provided by the Center for Prostate Disease Research of the US Department of Defense, resulting in a statistical atlas of spatial distribution of prostate cancer. Based on this atlas, a statistical predictive model was developed to optimize the needle biopsy sites, by maximizing the probability of detecting cancer. Experimental results using cross-validation show that the proposed method can detect cancer with a 99% success rate using seven needles, in these samples.

Duke Scholars

Judd Wendell Moul
Author Judd Wendell Moul Urology
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Published In

Med Image Anal

DOI

10.1016/j.media.2003.11.002

ISSN

1361-8415

Publication Date

June 2004

Volume

8

Issue

2

Start / End Page

139 / 150

Location

Netherlands

Related Subject Headings

  • Reproducibility of Results
  • Prostatic Neoplasms
  • Prostate
  • Probability
  • Nuclear Medicine & Medical Imaging
  • Models, Statistical
  • Models, Biological
  • Male
  • Imaging, Three-Dimensional
  • Image Processing, Computer-Assisted
 

Citation

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MLA
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Shen, D., Lao, Z., Zeng, J., Zhang, W., Sesterhenn, I. A., Sun, L., … Davatzikos, C. (2004). Optimized prostate biopsy via a statistical atlas of cancer spatial distribution. Med Image Anal, 8(2), 139–150. https://doi.org/10.1016/j.media.2003.11.002
Shen, Dinggang, Zhiqiang Lao, Jianchao Zeng, Wei Zhang, Isabel A. Sesterhenn, Leon Sun, Judd W. Moul, Edward H. Herskovits, Gabor Fichtinger, and Christos Davatzikos. “Optimized prostate biopsy via a statistical atlas of cancer spatial distribution.” Med Image Anal 8, no. 2 (June 2004): 139–50. https://doi.org/10.1016/j.media.2003.11.002.
Shen D, Lao Z, Zeng J, Zhang W, Sesterhenn IA, Sun L, et al. Optimized prostate biopsy via a statistical atlas of cancer spatial distribution. Med Image Anal. 2004 Jun;8(2):139–50.
Shen, Dinggang, et al. “Optimized prostate biopsy via a statistical atlas of cancer spatial distribution.” Med Image Anal, vol. 8, no. 2, June 2004, pp. 139–50. Pubmed, doi:10.1016/j.media.2003.11.002.
Shen D, Lao Z, Zeng J, Zhang W, Sesterhenn IA, Sun L, Moul JW, Herskovits EH, Fichtinger G, Davatzikos C. Optimized prostate biopsy via a statistical atlas of cancer spatial distribution. Med Image Anal. 2004 Jun;8(2):139–150.
Journal cover image

Published In

Med Image Anal

DOI

10.1016/j.media.2003.11.002

ISSN

1361-8415

Publication Date

June 2004

Volume

8

Issue

2

Start / End Page

139 / 150

Location

Netherlands

Related Subject Headings

  • Reproducibility of Results
  • Prostatic Neoplasms
  • Prostate
  • Probability
  • Nuclear Medicine & Medical Imaging
  • Models, Statistical
  • Models, Biological
  • Male
  • Imaging, Three-Dimensional
  • Image Processing, Computer-Assisted