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Targeting the androgen receptor--theory and practice.

Publication ,  Journal Article
Dreicer, R; Gleave, M; Kibel, AS; Thrasher, JB; Moul, JW
Published in: Urology
November 2011

Intensive investigation during the past 2 decades has led to an improved knowledge of the biology of the androgen receptor and a better understanding of how to assess for disease progression and the apparent existence of castrate-resistant prostate cancer. The result has been the clinical development of a new generation of hormonal therapy agents for achieving the androgen deprivation necessary to achieve castrate levels of circulating testosterone. It has also resulted in the realization that it is probably time to move away from using terms such as "hormone-refractory" and "androgen-independent" prostate cancer, given the clear evidence that significant, effective, ongoing suppression of testosterone, using better drugs and better assays, will continue to be the standard of care.

Duke Scholars

Published In

Urology

DOI

EISSN

1527-9995

Publication Date

November 2011

Volume

78

Issue

5 Suppl

Start / End Page

S482 / S484

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Testosterone
  • Prostatic Neoplasms
  • Male
  • Humans
  • Gonadotropin-Releasing Hormone
  • Androgen Receptor Antagonists
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Dreicer, R., Gleave, M., Kibel, A. S., Thrasher, J. B., & Moul, J. W. (2011). Targeting the androgen receptor--theory and practice. Urology, 78(5 Suppl), S482–S484. https://doi.org/10.1016/j.urology.2011.05.052
Dreicer, Robert, Martin Gleave, Adam S. Kibel, J Brantley Thrasher, and Judd W. Moul. “Targeting the androgen receptor--theory and practice.Urology 78, no. 5 Suppl (November 2011): S482–84. https://doi.org/10.1016/j.urology.2011.05.052.
Dreicer R, Gleave M, Kibel AS, Thrasher JB, Moul JW. Targeting the androgen receptor--theory and practice. Urology. 2011 Nov;78(5 Suppl):S482–4.
Dreicer, Robert, et al. “Targeting the androgen receptor--theory and practice.Urology, vol. 78, no. 5 Suppl, Nov. 2011, pp. S482–84. Pubmed, doi:10.1016/j.urology.2011.05.052.
Dreicer R, Gleave M, Kibel AS, Thrasher JB, Moul JW. Targeting the androgen receptor--theory and practice. Urology. 2011 Nov;78(5 Suppl):S482–S484.
Journal cover image

Published In

Urology

DOI

EISSN

1527-9995

Publication Date

November 2011

Volume

78

Issue

5 Suppl

Start / End Page

S482 / S484

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Testosterone
  • Prostatic Neoplasms
  • Male
  • Humans
  • Gonadotropin-Releasing Hormone
  • Androgen Receptor Antagonists
  • 3202 Clinical sciences
  • 1103 Clinical Sciences