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Maternal cytomegalovirus-specific immune responses and symptomatic postnatal cytomegalovirus transmission in very low-birth-weight preterm infants.

Publication ,  Journal Article
Ehlinger, EP; Webster, EM; Kang, HH; Cangialose, A; Simmons, AC; Barbas, KH; Burchett, SK; Gregory, ML; Puopolo, KM; Permar, SR
Published in: J Infect Dis
December 1, 2011

INTRODUCTION: Transmission of cytomegalovirus (CMV) via breast milk can lead to severe acute illness in very low-birth-weight (VLBW) preterm infants. Although the majority of CMV-seropositive women shed CMV in milk, symptomatic postnatal infection of VLBW infants occurs infrequently, suggesting that virologic or immunologic factors in milk may be associated with the risk and severity of postnatal CMV infection. METHODS: We investigated the magnitude of CMV-specific cellular and humoral immune responses in milk of 30 seropositive mothers of VLWB preterm infants and assessed their relationship to milk CMV load and symptomatic CMV transmission. RESULTS: Milk immunoglobulin G (IgG) avidity was inversely correlated to milk CMV load (r = -0.47; P = .009). However, milk CMV load and CMV-specific cellular and humoral immune responses were similar in mothers of VLBW infants with and those without symptomatic postnatal CMV infection. CONCLUSIONS: Similar immunologic parameters in milk of CMV-seropositive mothers of VLBW infants with and without symptomatic postnatal CMV infection indicate that screening milk by these parameters may not predict disease risk. However, the inverse correlation between milk CMV IgG avidity and CMV load may suggest that enhancement of maternal CMV-specific IgG responses could aid in reduction of CMV shedding into breast milk.

Duke Scholars

Published In

J Infect Dis

DOI

EISSN

1537-6613

Publication Date

December 1, 2011

Volume

204

Issue

11

Start / End Page

1672 / 1682

Location

United States

Related Subject Headings

  • Young Adult
  • Viral Load
  • Milk, Human
  • Microbiology
  • Leukocyte Count
  • Infectious Disease Transmission, Vertical
  • Infant, Very Low Birth Weight
  • Infant, Premature, Diseases
  • Infant, Premature
  • Infant, Newborn
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ehlinger, E. P., Webster, E. M., Kang, H. H., Cangialose, A., Simmons, A. C., Barbas, K. H., … Permar, S. R. (2011). Maternal cytomegalovirus-specific immune responses and symptomatic postnatal cytomegalovirus transmission in very low-birth-weight preterm infants. J Infect Dis, 204(11), 1672–1682. https://doi.org/10.1093/infdis/jir632
Ehlinger, Elizabeth P., Emily M. Webster, Helen H. Kang, Aislyn Cangialose, Adam C. Simmons, Kimberly H. Barbas, Sandra K. Burchett, Mary L. Gregory, Karen M. Puopolo, and Sallie R. Permar. “Maternal cytomegalovirus-specific immune responses and symptomatic postnatal cytomegalovirus transmission in very low-birth-weight preterm infants.J Infect Dis 204, no. 11 (December 1, 2011): 1672–82. https://doi.org/10.1093/infdis/jir632.
Ehlinger EP, Webster EM, Kang HH, Cangialose A, Simmons AC, Barbas KH, et al. Maternal cytomegalovirus-specific immune responses and symptomatic postnatal cytomegalovirus transmission in very low-birth-weight preterm infants. J Infect Dis. 2011 Dec 1;204(11):1672–82.
Ehlinger, Elizabeth P., et al. “Maternal cytomegalovirus-specific immune responses and symptomatic postnatal cytomegalovirus transmission in very low-birth-weight preterm infants.J Infect Dis, vol. 204, no. 11, Dec. 2011, pp. 1672–82. Pubmed, doi:10.1093/infdis/jir632.
Ehlinger EP, Webster EM, Kang HH, Cangialose A, Simmons AC, Barbas KH, Burchett SK, Gregory ML, Puopolo KM, Permar SR. Maternal cytomegalovirus-specific immune responses and symptomatic postnatal cytomegalovirus transmission in very low-birth-weight preterm infants. J Infect Dis. 2011 Dec 1;204(11):1672–1682.
Journal cover image

Published In

J Infect Dis

DOI

EISSN

1537-6613

Publication Date

December 1, 2011

Volume

204

Issue

11

Start / End Page

1672 / 1682

Location

United States

Related Subject Headings

  • Young Adult
  • Viral Load
  • Milk, Human
  • Microbiology
  • Leukocyte Count
  • Infectious Disease Transmission, Vertical
  • Infant, Very Low Birth Weight
  • Infant, Premature, Diseases
  • Infant, Premature
  • Infant, Newborn