Increased intestinal permeability in ankylosing spondylitis--primary lesion or drug effect?


Journal Article

We have found increased small intestinal permeability to 51Cr-ethylenediaminetetra acetate in patients with ankylosing spondylitis compared with controls. There is no significant difference between patients with ankylosing spondylitis and patients with rheumatoid arthritis taking non-steroidal anti-inflammatory drugs (NSAID). The increased intestinal permeability in ankylosing spondylitis is independent of disease activity. These findings suggest that the increased permeability is caused by NSAID treatment and is probably not a primary lesion of small bowel mucosa.

Full Text

Cited Authors

  • Morris, AJ; Howden, CW; Robertson, C; Duncan, A; Torley, H; Sturrock, RD; Russell, RI

Published Date

  • December 1991

Published In

Volume / Issue

  • 32 / 12

Start / End Page

  • 1470 - 1472

PubMed ID

  • 1773950

Pubmed Central ID

  • 1773950

Electronic International Standard Serial Number (EISSN)

  • 1468-3288

International Standard Serial Number (ISSN)

  • 0017-5749

Digital Object Identifier (DOI)

  • 10.1136/gut.32.12.1470


  • eng