Association and linkage studies of candidate genes involved in GABAergic neurotransmission in lithium-responsive bipolar disorder.


Journal Article

OBJECTIVE: To test for genetic linkage and association with GABAergic candidate genes in lithium-responsive bipolar disorder. DESIGN: Polymorphisms located in genes that code for GABRA3, GABRA5 and GABRB3 subunits of the GABAA receptor were investigated using association and linkage strategies. PARTICIPANTS: A total of 138 patients with bipolar 1 disorder with a clear response to lithium prophylaxis, selected from specialized lithium clinics in Canada and Europe that are part of the International Group for the Study of Lithium-Treated Patients, and 108 psychiatrically healthy controls. Families of 24 probands were suitable for linkage analysis. OUTCOME MEASURES: The association between the candidate genes and patients with bipolar disorder versus that of controls and genetic linkage within families. RESULTS: There was no significant association or linkage found between lithium-responsive bipolar disorder and the GABAergic candidate genes investigated. CONCLUSIONS: This study does not support a major role for the GABAergic candidate genes tested in lithium-responsive bipolar disorder.

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Cited Authors

  • Duffy, A; Turecki, G; Grof, P; Cavazzoni, P; Grof, E; Joober, R; Ahrens, B; Berghöfer, A; Müller-Oerlinghausen, B; Dvoráková, M; Libigerová, E; VojtÄ•chovský, M; Zvolský, P; Nilsson, A; Licht, RW; Rasmussen, NA; Schou, M; Vestergaard, P; Holzinger, A; Schumann, C; Thau, K; Robertson, C; Rouleau, GA; Alda, M

Published Date

  • September 2000

Published In

Volume / Issue

  • 25 / 4

Start / End Page

  • 353 - 358

PubMed ID

  • 11022400

Pubmed Central ID

  • 11022400

Electronic International Standard Serial Number (EISSN)

  • 1488-2434

International Standard Serial Number (ISSN)

  • 1180-4882


  • eng