Some statistical considerations in the analysis of case-control studies when the exposure variables are continuous measurements.

Published

Journal Article

This paper focuses on some statistical considerations in the estimation of dose-response in case-control studies when the exposure variables are continuous measurements. The first point is that the effects of differential variability in the exposure distributions over cases and controls cannot be differentiated from a true quadratic risk model. The second point is that when dealing with variables where zero denotes no exposure, it is important to treat the unexposed subjects separately from those who were exposed. Failure to do so can lead to differential variability among cases and controls and the resulting confounding with a quadratic risk model. Both of these points are illustrated by an example.

Full Text

Cited Authors

  • Robertson, C; Boyle, P; Hsieh, CC; Macfarlane, GJ; Maisonneuve, P

Published Date

  • March 1994

Published In

Volume / Issue

  • 5 / 2

Start / End Page

  • 164 - 170

PubMed ID

  • 8172991

Pubmed Central ID

  • 8172991

Electronic International Standard Serial Number (EISSN)

  • 1531-5487

International Standard Serial Number (ISSN)

  • 1044-3983

Digital Object Identifier (DOI)

  • 10.1097/00001648-199403000-00006

Language

  • eng