Slowed cognitive processing and high workload in Parkinson's disease.


Journal Article

It is suggested that cognitive slowing in Parkinson's disease (PD) may be evident on a task with high cognitive load. This hypothesis was tested using a workload design with a progressive increase in task difficulty, on a group of Parkinson patients and normal controls. Using measures of Reaction Time (RT) and Event Related Potentials (ERP), results showed that RT and ERP waveforms increased in line with task difficulty. The RT data was not significantly different between groups but the ERP showed a much reduced P300 in the patient group. These results are indicative of cognitive slowing in PD, at the stage of stimulus evaluation but not for response selection. An interpretation of the literature in terms of reduced activation in relation to cognitive slowing is discussed.

Full Text

Cited Authors

  • Robertson, C; Empson, J

Published Date

  • January 1999

Published In

Volume / Issue

  • 162 / 1

Start / End Page

  • 27 - 33

PubMed ID

  • 10064165

Pubmed Central ID

  • 10064165

Electronic International Standard Serial Number (EISSN)

  • 1878-5883

International Standard Serial Number (ISSN)

  • 0022-510X

Digital Object Identifier (DOI)

  • 10.1016/s0022-510x(98)00313-x


  • eng