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Prostate-specific antigen velocity based risk-adapted discontinuation of prostate cancer screening in elderly men.

Publication ,  Journal Article
Tang, P; Sun, L; Uhlman, MA; Robertson, CN; Polascik, TJ; Moul, JW
Published in: BJU Int
July 2011

OBJECTIVE: • To evaluate weather prostate-specific antigen (PSA) velocity could be used to stratify patients at risk of death from prostate cancer (PCa) and be useful in aiding decision making regarding PSA screening in elderly men, as previous studies have shown that PSA velocity can predict PCa risk. PATIENTS AND METHODS: • The cohort included 3,525 patients aged ≥ 75 years with two or more PSA tests before a diagnosis of PCa. Cox proportional hazard model was used to evaluate which variables at time of last PSA measurement were associated with death from PCa. • The rates of death from PCa after diagnosis in different PSA velocity groups were calculated. Kaplan-Meier and log rank test were used to assess the significant difference in death from PCa after diagnosis, stratified by PSA velocity cutoff. RESULTS: • On multivariate analysis, men with a PSA velocity of PSA velocity ≥ 0.45 ng/mL/year had a 4.8-fold higher risk of death from PCa as compared to men with a PSA velocity of < 0.45 ng/mL/year (p value = 0.013). After a median 6.5 (up to 16.9) years of follow-up from diagnosis, 1.4% of the men with a PSA velocity < 0.45 ng/mL/year had died of PCa as compared to 8.7% of those with a PSA velocity ≥ 0.45 ng/mL/year. • The cumulative rate of death from PCa after diagnosis, stratified by a PSA velocity of 0.45 ng/mL/year, was statistically different (log rank test, P < 0.001). CONCLUSION: • Men age ≥ 75 years old with a PSA velocity of <0.45 ng/mL/year are unlikely to die of PCa. It may be safe to discontinue PSA screening in these men.

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Published In

BJU Int

DOI

EISSN

1464-410X

Publication Date

July 2011

Volume

108

Issue

1

Start / End Page

44 / 48

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Unnecessary Procedures
  • Time Factors
  • Prostatic Neoplasms
  • Prostate-Specific Antigen
  • Prognosis
  • Male
  • Humans
  • Epidemiologic Methods
  • Early Detection of Cancer
 

Citation

APA
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ICMJE
MLA
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Tang, P., Sun, L., Uhlman, M. A., Robertson, C. N., Polascik, T. J., & Moul, J. W. (2011). Prostate-specific antigen velocity based risk-adapted discontinuation of prostate cancer screening in elderly men. BJU Int, 108(1), 44–48. https://doi.org/10.1111/j.1464-410X.2010.09812.x
Tang, Ping, Leon Sun, Matthew A. Uhlman, Cary N. Robertson, Thomas J. Polascik, and Judd W. Moul. “Prostate-specific antigen velocity based risk-adapted discontinuation of prostate cancer screening in elderly men.BJU Int 108, no. 1 (July 2011): 44–48. https://doi.org/10.1111/j.1464-410X.2010.09812.x.
Tang P, Sun L, Uhlman MA, Robertson CN, Polascik TJ, Moul JW. Prostate-specific antigen velocity based risk-adapted discontinuation of prostate cancer screening in elderly men. BJU Int. 2011 Jul;108(1):44–8.
Tang, Ping, et al. “Prostate-specific antigen velocity based risk-adapted discontinuation of prostate cancer screening in elderly men.BJU Int, vol. 108, no. 1, July 2011, pp. 44–48. Pubmed, doi:10.1111/j.1464-410X.2010.09812.x.
Tang P, Sun L, Uhlman MA, Robertson CN, Polascik TJ, Moul JW. Prostate-specific antigen velocity based risk-adapted discontinuation of prostate cancer screening in elderly men. BJU Int. 2011 Jul;108(1):44–48.
Journal cover image

Published In

BJU Int

DOI

EISSN

1464-410X

Publication Date

July 2011

Volume

108

Issue

1

Start / End Page

44 / 48

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Unnecessary Procedures
  • Time Factors
  • Prostatic Neoplasms
  • Prostate-Specific Antigen
  • Prognosis
  • Male
  • Humans
  • Epidemiologic Methods
  • Early Detection of Cancer