Molecular imaging of small animals with a triple-head SPECT system using pinhole collimation.

Journal Article (Journal Article)

Pinhole collimation yields high sensitivity when the distance from the object to the aperture is small, as in the case of imaging small animals. Fine-resolution images may be obtained when the magnification is large since this mitigates the effect of detector resolution. Large magnifications in pinhole single-photon emission computed tomography (SPECT) may be obtained by using a collimator whose focal length is many times the radius of rotation. This may be achieved without truncation if the gamma camera is large. We describe a commercially available clinical scanner mated with pinhole collimation and an external linear stage. The pinhole collimation gives high magnification. The linear stage allows for helical pinhole SPECT. We have used the system to image radiolabeled molecules in phantoms and small animals.

Full Text

Duke Authors

Cited Authors

  • Metzler, SD; Jaszczak, RJ; Patil, NH; Vemulapalli, S; Akabani, G; Chin, BB

Published Date

  • July 2005

Published In

Volume / Issue

  • 24 / 7

Start / End Page

  • 853 - 862

PubMed ID

  • 16011314

International Standard Serial Number (ISSN)

  • 0278-0062

Digital Object Identifier (DOI)

  • 10.1109/tmi.2005.848357


  • eng

Conference Location

  • United States