Molecular imaging of small animals with a triple-head SPECT system using pinhole collimation.
Journal Article (Journal Article)
Pinhole collimation yields high sensitivity when the distance from the object to the aperture is small, as in the case of imaging small animals. Fine-resolution images may be obtained when the magnification is large since this mitigates the effect of detector resolution. Large magnifications in pinhole single-photon emission computed tomography (SPECT) may be obtained by using a collimator whose focal length is many times the radius of rotation. This may be achieved without truncation if the gamma camera is large. We describe a commercially available clinical scanner mated with pinhole collimation and an external linear stage. The pinhole collimation gives high magnification. The linear stage allows for helical pinhole SPECT. We have used the system to image radiolabeled molecules in phantoms and small animals.
Full Text
Duke Authors
Cited Authors
- Metzler, SD; Jaszczak, RJ; Patil, NH; Vemulapalli, S; Akabani, G; Chin, BB
Published Date
- July 2005
Published In
Volume / Issue
- 24 / 7
Start / End Page
- 853 - 862
PubMed ID
- 16011314
International Standard Serial Number (ISSN)
- 0278-0062
Digital Object Identifier (DOI)
- 10.1109/tmi.2005.848357
Language
- eng
Conference Location
- United States