Modulation of thyroidal radioiodine uptake by theophylline.


Journal Article

Diagnostic and therapeutic use of radioiodine in the management of thyroid disorders depends on the ability of thyroid cells to concentrate radioiodine, a process regulated by thyrotropin and dependent on the intracellular increase in cAMP. We tested the ability of theophylline, a drug known to increase intracellular cAMP via inhibition of phosphodiesterase, to modulate the thyroidal radioiodine uptake in FRTL-5 cells, in mice and in humans. In FRTL-5 cells, theophylline increased the uptake of radioactive iodine and intracellular cAMP only at low concentrations (1 microM). In mice, theophylline increased slightly the radioiodine uptake, although this increase varied from 1.5- to 6.6-fold. In humans, theophylline decreased slightly the radioiodine uptake, a decrease that became more pronounced with time after radioiodine administration. These studies suggest that theophylline modulates the radioiodine uptake in a dose-dependent fashion, although the modulation is mild and probably not applicable to the clinical setting.

Full Text

Duke Authors

Cited Authors

  • Lee, JM; Zemans, RL; Hejazi, M; Chin, BB; Ladenson, PW; Caturegli, P

Published Date

  • October 2004

Published In

Volume / Issue

  • 77 / 2

Start / End Page

  • 116 - 120

PubMed ID

  • 15351234

Pubmed Central ID

  • 15351234

International Standard Serial Number (ISSN)

  • 0014-4800

Digital Object Identifier (DOI)

  • 10.1016/j.yexmp.2004.05.002


  • eng

Conference Location

  • Netherlands