Automated platelet counters: a comparative evaluation of latest instrumentation.


Journal Article

An extensive evaluation of performance characteristics and accuracy of clinical results for two automated multiparameter whole-blood cell counters (the Coulter Counter Model S-Plus and the Ortho ELT-8) and two single-parameter semiautomated platelet counters (the J. T. Baker MK-4/HC and the Clay-Adams Ultra-Flo 100) is described. Results of comparative assays performed on more than 1,200 clinical specimens are analyzed. These results are compared with manual determinations where appropriate. Particular attention is accorded to the accuracy of platelet counts, especially at abnormal levels below 70 X 10(3)/cu mm, where falsely elevated platelet counts may lead to serious clinical consequences. Both multiparameter instruments yielded accurate results, with the exception of low values reported by the ELT-8 for mean corpuscular volumes above 100 cu micrometer. Results for platelet counts were accurate for most specimens on all four instruments; the ELT-8 was the most reliable (P < 0.01), especially for the critically low counts. Although no instrument is infallible in determining platelet counts at all levels, the authors conclude that addition of platelet-counting capability represents a significant advancement over existing instrumentation.

Full Text

Duke Authors

Cited Authors

  • Mayer, K; Chin, B; Magnes, J; Thaler, HT; Lotspeich, C; Baisley, A

Published Date

  • August 1, 1980

Published In

Volume / Issue

  • 74 / 2

Start / End Page

  • 135 - 150

PubMed ID

  • 7405891

Pubmed Central ID

  • 7405891

International Standard Serial Number (ISSN)

  • 0002-9173

Digital Object Identifier (DOI)

  • 10.1093/ajcp/74.2.135


  • eng

Conference Location

  • England