Vesicoureteral reflux: current trends in diagnosis, screening, and treatment.

Journal Article (Journal Article;Review;Systematic Review)

CONTEXT: Vesicoureteral reflux (VUR) is present in approximately 1% of children in North America and Europe and is associated with an increased risk of pyelonephritis and renal scarring. Despite its prevalence and potential morbidity, however, many aspects of VUR management are controversial. OBJECTIVE: Review the evidence surrounding current controversies in VUR diagnosis, screening, and treatment. EVIDENCE ACQUISITION: A systematic review was performed of Medline, Embase, Prospero, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews,, and the most recent guidelines of relevant medical specialty organizations. EVIDENCE SYNTHESIS: We objectively assessed and summarized the published data, focusing on recent areas of controversy relating to VUR screening, diagnosis, and treatment. CONCLUSIONS: The evidence base for many current management patterns in VUR is limited. Areas that could significantly benefit from additional future research include improved identification of children who are at risk for VUR-related renal morbidity, improved stratification tools for determining which children would benefit most from which VUR treatment option, and improved reporting of long-term outcomes of VUR treatments.

Full Text

Duke Authors

Cited Authors

  • Routh, JC; Bogaert, GA; Kaefer, M; Manzoni, G; Park, JM; Retik, AB; Rushton, HG; Snodgrass, WT; Wilcox, DT

Published Date

  • April 2012

Published In

Volume / Issue

  • 61 / 4

Start / End Page

  • 773 - 782

PubMed ID

  • 22264440

Electronic International Standard Serial Number (EISSN)

  • 1873-7560

Digital Object Identifier (DOI)

  • 10.1016/j.eururo.2012.01.002


  • eng

Conference Location

  • Switzerland