Antibiotic use and misuse in the neonatal intensive care unit.

Journal Article (Journal Article;Review)

Neonatal sepsis causes significant morbidity and mortality, especially in preterm infants. Clinicians are compelled to treat with empiric antibiotics at the first signs of suspected sepsis. Broad-spectrum antibiotics and prolonged treatment with empiric antibiotics are associated with adverse outcomes. Most common neonatal pathogens are susceptible to narrow-spectrum antibiotics. The choice of antibiotic and duration of empiric treatment are strongly associated with center-based risk factors. Clinicians should treat with short courses of narrow-spectrum antibiotics whenever possible, choosing the antibiotics and treatment duration to balance the risks of potentially untreated sepsis against the adverse effects of treatment in infants with sterile cultures.

Full Text

Duke Authors

Cited Authors

  • Tripathi, N; Cotten, CM; Smith, PB

Published Date

  • March 2012

Published In

Volume / Issue

  • 39 / 1

Start / End Page

  • 61 - 68

PubMed ID

  • 22341537

Pubmed Central ID

  • PMC3285418

Electronic International Standard Serial Number (EISSN)

  • 1557-9840

Digital Object Identifier (DOI)

  • 10.1016/j.clp.2011.12.003


  • eng

Conference Location

  • United States