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Characterizing effects of subthalamic nucleus deep brain stimulation on methamphetamine-induced circling behavior in hemi-Parkinsonian rats.

Publication ,  Journal Article
So, RQ; McConnell, GC; August, AT; Grill, WM
Published in: IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
September 2012

The unilateral 6-hydroxydopamine (6-OHDA) lesioned rat model is frequently used to study the effects of subthalamic nucleus (STN) deep brain stimulation (DBS) for the treatment of Parkinson's disease. However, systematic knowledge of the effects of DBS parameters on behavior in this animal model is lacking. The goal of this study was to characterize the effects of DBS on methamphetamine-induced circling in the unilateral 6-OHDA lesioned rat. DBS parameters tested include stimulation amplitude, stimulation frequency, methamphetamine dose, stimulation polarity, and anatomical location of the electrode. When an appropriate stimulation amplitude and dose of methamphetamine were applied, high-frequency stimulation (> 130 Hz), but not low frequency stimulation (< 10 Hz), reversed the bias in ipsilateral circling without inhibiting movement. This characteristic frequency tuning profile was only generated when at least one electrode used during bipolar stimulation was located within the STN. No difference was found between bipolar stimulation and monopolar stimulation when the most effective electrode contact was selected, indicating that monopolar stimulation could be used in future experiments. Methamphetamine-induced circling is a simple, reliable, and sensitive behavioral test and holds potential for high-throughput study of the effects of STN DBS in unilaterally lesioned rats.

Duke Scholars

Published In

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society

DOI

EISSN

1558-0210

ISSN

1534-4320

Publication Date

September 2012

Volume

20

Issue

5

Start / End Page

626 / 635

Related Subject Headings

  • Treatment Outcome
  • Subthalamic Nucleus
  • Rats, Long-Evans
  • Rats
  • Parkinsonian Disorders
  • Methamphetamine
  • Mental Disorders
  • Deep Brain Stimulation
  • Biomedical Engineering
  • Behavior, Animal
 

Citation

APA
Chicago
ICMJE
MLA
NLM
So, R. Q., McConnell, G. C., August, A. T., & Grill, W. M. (2012). Characterizing effects of subthalamic nucleus deep brain stimulation on methamphetamine-induced circling behavior in hemi-Parkinsonian rats. IEEE Transactions on Neural Systems and Rehabilitation Engineering : A Publication of the IEEE Engineering in Medicine and Biology Society, 20(5), 626–635. https://doi.org/10.1109/tnsre.2012.2197761
So, Rosa Q., George C. McConnell, Auriel T. August, and Warren M. Grill. “Characterizing effects of subthalamic nucleus deep brain stimulation on methamphetamine-induced circling behavior in hemi-Parkinsonian rats.IEEE Transactions on Neural Systems and Rehabilitation Engineering : A Publication of the IEEE Engineering in Medicine and Biology Society 20, no. 5 (September 2012): 626–35. https://doi.org/10.1109/tnsre.2012.2197761.
So RQ, McConnell GC, August AT, Grill WM. Characterizing effects of subthalamic nucleus deep brain stimulation on methamphetamine-induced circling behavior in hemi-Parkinsonian rats. IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society. 2012 Sep;20(5):626–35.
So, Rosa Q., et al. “Characterizing effects of subthalamic nucleus deep brain stimulation on methamphetamine-induced circling behavior in hemi-Parkinsonian rats.IEEE Transactions on Neural Systems and Rehabilitation Engineering : A Publication of the IEEE Engineering in Medicine and Biology Society, vol. 20, no. 5, Sept. 2012, pp. 626–35. Epmc, doi:10.1109/tnsre.2012.2197761.
So RQ, McConnell GC, August AT, Grill WM. Characterizing effects of subthalamic nucleus deep brain stimulation on methamphetamine-induced circling behavior in hemi-Parkinsonian rats. IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society. 2012 Sep;20(5):626–635.

Published In

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society

DOI

EISSN

1558-0210

ISSN

1534-4320

Publication Date

September 2012

Volume

20

Issue

5

Start / End Page

626 / 635

Related Subject Headings

  • Treatment Outcome
  • Subthalamic Nucleus
  • Rats, Long-Evans
  • Rats
  • Parkinsonian Disorders
  • Methamphetamine
  • Mental Disorders
  • Deep Brain Stimulation
  • Biomedical Engineering
  • Behavior, Animal