Bilateral pudendal afferent stimulation improves bladder emptying in rats with urinary retention.

Published

Journal Article

To determine whether bilateral electrical stimulation (BiES) of the transected pudendal sensory nerves could further enhance the voiding efficiency beyond that produced by unilateral electrical stimulation (UniES) of transected pudendal afferents in rats with urinary retention.The efficiency of bladder emptying with either UniES or BiES of pudendal nerve afferents was measured after acute bilateral transection of the sensory branch of the pudendal nerve. The effects of UniES and BiES on voiding in a partially denervated bladder and acute spinal transection, respectively, were determined.The voiding efficiency (VE) was reduced from 69 to 22% after bilateral transection of the sensory branch of the pudendal nerve. UniES or BiES increased the VE to 49-62%. Although in most instances BiES consistently generated more efficient bladder emptying than did UniES, these differences were not significant. Both UniES and BiES increased VE after unilateral pelvic nerve transection, demonstrating efficacy in a partially denervated bladder. The enhancement of VE by either UniES or BiES was preserved after acute T(9)-T(10), demonstrating the spinal origin of this augmenting reflex.The results of the present study are consistent with an essential role for pudendal sensory feedback in efficient bladder emptying, and unilateral and bilateral electrical activation of pudendal nerve afferents are equally efficient in improving bladder emptying in an animal model of urinary retention. This could provide an approach to improve bladder emptying in patients with non-obstructive urinary retention.

Full Text

Duke Authors

Cited Authors

  • Chen, S-C; Grill, WM; Fan, W-J; Kou, YR; Lin, YS; Lai, C-H; Peng, C-W

Published Date

  • April 2012

Published In

Volume / Issue

  • 109 / 7

Start / End Page

  • 1051 - 1058

PubMed ID

  • 21883860

Pubmed Central ID

  • 21883860

Electronic International Standard Serial Number (EISSN)

  • 1464-410X

International Standard Serial Number (ISSN)

  • 1464-4096

Digital Object Identifier (DOI)

  • 10.1111/j.1464-410X.2011.10526.x

Language

  • eng