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Contrast material administration protocols for 64-MDCT angiography: altering volume and rate and use of a saline chaser to better match the imaging window--physiologic phantom study.

Publication ,  Journal Article
Coursey, CA; Nelson, RC; Weber, PW; Howle, LE; Nichols, EB; Marin, D; DeLong, D
Published in: AJR Am J Roentgenol
December 2009

OBJECTIVE: The purpose of our study was to evaluate the effect of varying volumes and rates of contrast material, use of a saline chaser, and cardiac output on aortic enhancement characteristics in MDCT angiography (MDCTA) using a physiologic phantom. MATERIALS AND METHODS: Volumes of 75, 100, and 125 mL of iopamidol, 370 mg I/mL, were administered at rates of 4, 6, and 8 mL/s. The effect of a saline chaser (50 mL of normal saline, 8 mL/s) was evaluated for each volume and rate combination. Normal, reduced (33% and 50%), and increased (25%) cardiac outputs were simulated. Peak aortic enhancement and duration of peak aortic enhancement were recorded. Analysis of variance models were run with these effects, and the estimated mean levels for the sets of factor combinations were determined. RESULTS: Lowering the volume of contrast material resulted in reduced peak enhancement (example, -56.2 HU [p < 0.0001] with 75 vs 125 mL) and reduced duration of 75% peak enhancement (example, -9.0 seconds [p < 0.0001] with 75 vs 125 mL). Increasing the rate resulted in increased peak enhancement (example, 104.5 HU [p < 0.0001] with a rate of 8 vs 4 mL/s) and decreased duration of 75% peak enhancement (example, -13.0 seconds [p < 0.001]). Use of a saline chaser resulted in increased peak enhancement, and this increase was inversely proportional to contrast material volume. Peak enhancement increased when reduced cardiac output was simulated. Peak enhancement decreased when increased cardiac output was simulated. CONCLUSION: Reducing contrast material volume from 125 to 75 mL, increasing the rate to 6 or 8 mL/s, and use of a saline chaser result in an aortic enhancement profile that better matches the approximately 5-second imaging window possible with 64-MDCTA of the abdomen and pelvis. Even smaller volumes of contrast material may be adequate in patients with reduced cardiac output.

Duke Scholars

Published In

AJR Am J Roentgenol

DOI

EISSN

1546-3141

Publication Date

December 2009

Volume

193

Issue

6

Start / End Page

1568 / 1575

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Sodium Chloride
  • Radiographic Image Interpretation, Computer-Assisted
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Iopamidol
  • Humans
  • Equipment Design
  • Coronary Angiography
  • Contrast Media
 

Citation

APA
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ICMJE
MLA
NLM
Coursey, C. A., Nelson, R. C., Weber, P. W., Howle, L. E., Nichols, E. B., Marin, D., & DeLong, D. (2009). Contrast material administration protocols for 64-MDCT angiography: altering volume and rate and use of a saline chaser to better match the imaging window--physiologic phantom study. AJR Am J Roentgenol, 193(6), 1568–1575. https://doi.org/10.2214/AJR.09.2670
Coursey, Courtney A., Rendon C. Nelson, Paul W. Weber, Laurens E. Howle, Eli B. Nichols, Daniele Marin, and David DeLong. “Contrast material administration protocols for 64-MDCT angiography: altering volume and rate and use of a saline chaser to better match the imaging window--physiologic phantom study.AJR Am J Roentgenol 193, no. 6 (December 2009): 1568–75. https://doi.org/10.2214/AJR.09.2670.
Coursey, Courtney A., et al. “Contrast material administration protocols for 64-MDCT angiography: altering volume and rate and use of a saline chaser to better match the imaging window--physiologic phantom study.AJR Am J Roentgenol, vol. 193, no. 6, Dec. 2009, pp. 1568–75. Pubmed, doi:10.2214/AJR.09.2670.
Coursey CA, Nelson RC, Weber PW, Howle LE, Nichols EB, Marin D, DeLong D. Contrast material administration protocols for 64-MDCT angiography: altering volume and rate and use of a saline chaser to better match the imaging window--physiologic phantom study. AJR Am J Roentgenol. 2009 Dec;193(6):1568–1575.

Published In

AJR Am J Roentgenol

DOI

EISSN

1546-3141

Publication Date

December 2009

Volume

193

Issue

6

Start / End Page

1568 / 1575

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Sodium Chloride
  • Radiographic Image Interpretation, Computer-Assisted
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Iopamidol
  • Humans
  • Equipment Design
  • Coronary Angiography
  • Contrast Media