Stereocomplexes Formed From Select Oligomers of Polymer d-lactic Acid (PDLA) and l-lactate May Inhibit Growth of Cancer Cells and Help Diagnose Aggressive Cancers-Applications of the Warburg Effect.

Published online

Journal Article

It is proposed that select oligomers of polymer d-lactic acid (PDLA) will form a stereocomplex with l-lactate in vivo, producing lactate deficiency in tumor cells. Those cancer cells that utilize transport of lactate to maintain electrical neutrality may cease to multiply or die because of lactate trapping, and those cancer cells that benefit from utilization of extracellular lactate may be impaired. Intracellular trapping of lactate produces a different physiology than inhibition of LDH because the cell loses the option of shuttling pyruvate to an alternative pathway to produce an anion. Conjugated with stains or fluorescent probes, PDLA oligomers may be an agent for the diagnosis of tissue lactate and possibly cell differentiation in biopsy specimens. Preliminary experimental evidence is presented confirming that PDLA in high concentrations is cytotoxic and that l-lactate forms a presumed stereocomplex with PDLA. Future work should be directed at isolation of biologically active oligomers of PDLA.

Full Text

Duke Authors

Cited Authors

  • Goldberg, JS

Published Date

  • February 15, 2011

Published In

Volume / Issue

  • 5 /

Start / End Page

  • 1 - 10

PubMed ID

  • 21487535

Pubmed Central ID

  • 21487535

Electronic International Standard Serial Number (EISSN)

  • 1177-391X

Digital Object Identifier (DOI)

  • 10.4137/PMC.S6229

Language

  • eng

Conference Location

  • United States