Convection enhanced delivery of macromolecules for brain tumors.


Journal Article

The blood brain barrier (BBB) poses a significant challenge for drug delivery of macromolecules into the brain. Convection-enhanced delivery (CED) circumvents the BBB through direct intracerebral infusion using a hydrostatic pressure gradient to transfer therapeutic compounds. The efficacy of CED is dependent on the distribution of the therapeutic agent to the targeted region. Here we present a review of convection enhanced delivery of macromolecules, emphasizing the role of tracers in enabling effective delivery anddiscuss current challenges in the field.

Full Text

Duke Authors

Cited Authors

  • Mehta, AI; Choi, BD; Ajay, D; Raghavan, R; Brady, M; Friedman, AH; Pastan, I; Bigner, DD; Sampson, JH

Published Date

  • December 2012

Published In

Volume / Issue

  • 9 / 4

Start / End Page

  • 305 - 310

PubMed ID

  • 22339074

Pubmed Central ID

  • 22339074

Electronic International Standard Serial Number (EISSN)

  • 1875-6220

Digital Object Identifier (DOI)

  • 10.2174/157016312803305951


  • eng

Conference Location

  • United Arab Emirates