Imaging of convection enhanced delivery of toxins in humans.

Journal Article (Journal Article;Review)

Drug delivery of immunotoxins to brain tumors circumventing the blood brain barrier is a significant challenge. Convection-enhanced delivery (CED) circumvents the blood brain barrier through direct intracerebral application using a hydrostatic pressure gradient to percolate therapeutic compounds throughout the interstitial spaces of infiltrated brain and tumors. The efficacy of CED is determined through the distribution of the therapeutic agent to the targeted region. The vast majority of patients fail to receive a significant amount of coverage of the area at risk for tumor recurrence. Understanding this challenge, it is surprising that so little work has been done to monitor the delivery of therapeutic agents using this novel approach. Here we present a review of imaging in convection enhanced delivery monitoring of toxins in humans, and discuss future challenges in the field.

Full Text

Duke Authors

Cited Authors

  • Mehta, AI; Choi, BD; Raghavan, R; Brady, M; Friedman, AH; Bigner, DD; Pastan, I; Sampson, JH

Published Date

  • March 2011

Published In

Volume / Issue

  • 3 / 3

Start / End Page

  • 201 - 206

PubMed ID

  • 22069706

Pubmed Central ID

  • PMC3202819

Electronic International Standard Serial Number (EISSN)

  • 2072-6651

Digital Object Identifier (DOI)

  • 10.3390/toxins3030201


  • eng

Conference Location

  • Switzerland