Proteoglycan signaling co-receptors: roles in cell adhesion, migration and invasion.

Journal Article (Journal Article;Review)

Signaling co-receptors are diverse, multifunctional components of most major signaling pathways, with roles in mediating and regulating signaling in both physiological and pathophysiological circumstances. Many of these signaling co-receptors, including CD44, glypicans, neuropilins, syndecans and TssRIII/betaglycan are also proteoglycans. Like other co-receptors, these proteoglycan signaling co-receptors can bind multiple ligands, promoting the formation of receptor signaling complexes and regulating signaling at the cell surface. The proteoglycan signaling co-receptors can also function as structural molecules to regulate adhesion, cell migration, morphogenesis and differentiation. Through a balance of these signaling and structural roles, proteoglycan signaling co-receptors can have either tumor promoting or tumor suppressing functions. Defining the role and mechanism of action of these proteoglycan signaling co-receptors should enable more effective targeting of these co-receptors and their respective pathways for the treatment of human disease.

Full Text

Duke Authors

Cited Authors

  • Mythreye, K; Blobe, GC

Published Date

  • November 2009

Published In

Volume / Issue

  • 21 / 11

Start / End Page

  • 1548 - 1558

PubMed ID

  • 19427900

Pubmed Central ID

  • PMC2735586

Electronic International Standard Serial Number (EISSN)

  • 1873-3913

Digital Object Identifier (DOI)

  • 10.1016/j.cellsig.2009.05.001


  • eng

Conference Location

  • England