Proteoglycan signaling co-receptors: roles in cell adhesion, migration and invasion.
Journal Article (Journal Article;Review)
Signaling co-receptors are diverse, multifunctional components of most major signaling pathways, with roles in mediating and regulating signaling in both physiological and pathophysiological circumstances. Many of these signaling co-receptors, including CD44, glypicans, neuropilins, syndecans and TssRIII/betaglycan are also proteoglycans. Like other co-receptors, these proteoglycan signaling co-receptors can bind multiple ligands, promoting the formation of receptor signaling complexes and regulating signaling at the cell surface. The proteoglycan signaling co-receptors can also function as structural molecules to regulate adhesion, cell migration, morphogenesis and differentiation. Through a balance of these signaling and structural roles, proteoglycan signaling co-receptors can have either tumor promoting or tumor suppressing functions. Defining the role and mechanism of action of these proteoglycan signaling co-receptors should enable more effective targeting of these co-receptors and their respective pathways for the treatment of human disease.
Full Text
Duke Authors
Cited Authors
- Mythreye, K; Blobe, GC
Published Date
- November 2009
Published In
Volume / Issue
- 21 / 11
Start / End Page
- 1548 - 1558
PubMed ID
- 19427900
Pubmed Central ID
- PMC2735586
Electronic International Standard Serial Number (EISSN)
- 1873-3913
Digital Object Identifier (DOI)
- 10.1016/j.cellsig.2009.05.001
Language
- eng
Conference Location
- England