Aging is not associated with bone marrow-resident progenitor cell depletion.
Published
Journal Article
Changes in progenitor cell biology remain at the forefront of many theories of biologic aging, but there are limited studies evaluating this in humans. Aging has been associated with a progressive depletion of circulating progenitor cells, but age-related bone marrow-resident progenitor cell depletion has not been systematically determined in humans. Patients undergoing total hip replacement were consented, and bone marrow and peripheral progenitor cells were enumerated based on aldehyde dehydrogenase activity and CD34 and CD133 expression. Circulating progenitors demonstrated an age-dependent decline. In contrast, marrow-resident progenitor cell content demonstrated no age association with any progenitor cell subtype. In humans, aging is associated with depletion of circulating, but not marrow-resident, progenitors. This finding has impact on the mechanism(s) responsible for age-related changes in circulating stem cells and important implications for the use of autologous marrow for the treatment of age-related diseases.
Full Text
Duke Authors
Cited Authors
- Povsic, TJ; Zhou, J; Adams, SD; Bolognesi, MP; Attarian, DE; Peterson, ED
Published Date
- October 2010
Published In
Volume / Issue
- 65 / 10
Start / End Page
- 1042 - 1050
PubMed ID
- 20591876
Pubmed Central ID
- 20591876
Electronic International Standard Serial Number (EISSN)
- 1758-535X
Digital Object Identifier (DOI)
- 10.1093/gerona/glq110
Language
- eng
Conference Location
- United States