Aging is not associated with bone marrow-resident progenitor cell depletion.

Published

Journal Article

Changes in progenitor cell biology remain at the forefront of many theories of biologic aging, but there are limited studies evaluating this in humans. Aging has been associated with a progressive depletion of circulating progenitor cells, but age-related bone marrow-resident progenitor cell depletion has not been systematically determined in humans. Patients undergoing total hip replacement were consented, and bone marrow and peripheral progenitor cells were enumerated based on aldehyde dehydrogenase activity and CD34 and CD133 expression. Circulating progenitors demonstrated an age-dependent decline. In contrast, marrow-resident progenitor cell content demonstrated no age association with any progenitor cell subtype. In humans, aging is associated with depletion of circulating, but not marrow-resident, progenitors. This finding has impact on the mechanism(s) responsible for age-related changes in circulating stem cells and important implications for the use of autologous marrow for the treatment of age-related diseases.

Full Text

Duke Authors

Cited Authors

  • Povsic, TJ; Zhou, J; Adams, SD; Bolognesi, MP; Attarian, DE; Peterson, ED

Published Date

  • October 2010

Published In

Volume / Issue

  • 65 / 10

Start / End Page

  • 1042 - 1050

PubMed ID

  • 20591876

Pubmed Central ID

  • 20591876

Electronic International Standard Serial Number (EISSN)

  • 1758-535X

International Standard Serial Number (ISSN)

  • 1079-5006

Digital Object Identifier (DOI)

  • 10.1093/gerona/glq110

Language

  • eng