Neonatal fungal infections: when to treat?


Journal Article (Review)

Candida infections are a major cause of morbidity and mortality in neonatal intensive care units. Mortality following Candida bloodstream infections is as high as 40%, and neurodevelopmental impairment is common among survivors. Because invasive fungal infections are common and extremely difficult to diagnose, empirical treatment with antifungal therapy should be considered in high-risk, low-birth-weight infants who fail to quickly respond to empirical antibacterial treatment. Risk factors to consider when deciding to administer empirical antifungal therapy include: prior exposure to third-generation cephalosporins, extreme prematurity, and presence of central venous catheters.

Full Text

Duke Authors

Cited Authors

  • Hsieh, E; Smith, PB; Jacqz-Aigrain, E; Kaguelidou, F; Cohen-Wolkowiez, M; Manzoni, P; Benjamin, DK

Published Date

  • May 2012

Published In

Volume / Issue

  • 88 Suppl 2 /

Start / End Page

  • S6 - S10

PubMed ID

  • 22633516

Pubmed Central ID

  • 22633516

Electronic International Standard Serial Number (EISSN)

  • 1872-6232

Digital Object Identifier (DOI)

  • 10.1016/S0378-3782(12)70004-X


  • eng

Conference Location

  • Ireland