Pharmacokinetics and tolerability of single-dose daptomycin in young infants.


Journal Article

BACKGROUND: Daptomycin is approved for the treatment of complicated skin and skin-structure infections and Staphylococcus aureus bacteremia. We sought to characterize daptomycin single-dose pharmacokinetics and tolerability in young infants. METHODS: Subjects < 120 days of age with suspected systemic infections were eligible for inclusion. Each subject was given a single 6 mg/kg intravenous dose of daptomycin. An average of 4 postdose concentrations per infant was obtained. RESULTS: Data from 20 infants are presented. Median gestational age at birth and postnatal age were 32 weeks (range: 23, 40) and 3 days (1, 85), respectively. The median area under the concentration curve at 24 hours, volume of distribution, total body clearance and half-life of daptomycin were 262.4 mg×h/L (166.7, 340.2), 0.21 L/kg (0.11, 0.34), 0.021 L/h/kg (0.016, 0.034) and 6.2 hours (3.7, 9.0), respectively. No adverse events related to daptomycin were observed, including changes in creatine phosphokinase concentrations. CONCLUSIONS: Daptomycin clearance in young infants was similar to that in children 2-6 years of age and higher than that observed in adolescents and adults.

Full Text

Duke Authors

Cited Authors

  • Cohen-Wolkowiez, M; Watt, KM; Hornik, CP; Benjamin, DK; Smith, PB

Published Date

  • September 2012

Published In

Volume / Issue

  • 31 / 9

Start / End Page

  • 935 - 937

PubMed ID

  • 22627869

Pubmed Central ID

  • 22627869

Electronic International Standard Serial Number (EISSN)

  • 1532-0987

Digital Object Identifier (DOI)

  • 10.1097/INF.0b013e31825d2fa2


  • eng

Conference Location

  • United States