Therapeutic monitoring of voriconazole in children less than three years of age: a case report and summary of voriconazole concentrations for ten children.

Journal Article (Journal Article)

Voriconazole is the treatment of choice for invasive aspergillosis and its use is increasing in pediatrics. Minimal pharmacokinetic data exist in young children. We report voriconazole concentrations for 10 children <3 years of age and pharmacokinetic parameters for 1 infant who had therapeutic drug monitoring performed. Trough concentrations were unpredictable based on dose, highlighting the need to follow values during therapy.

Full Text

Duke Authors

Cited Authors

  • Doby, EH; Benjamin, DK; Blaschke, AJ; Ward, RM; Pavia, AT; Martin, PL; Driscoll, TA; Cohen-Wolkowiez, M; Moran, C

Published Date

  • June 2012

Published In

Volume / Issue

  • 31 / 6

Start / End Page

  • 632 - 635

PubMed ID

  • 22301479

Pubmed Central ID

  • PMC3356483

Electronic International Standard Serial Number (EISSN)

  • 1532-0987

Digital Object Identifier (DOI)

  • 10.1097/INF.0b013e31824acc33

Language

  • eng

Conference Location

  • United States