Sepsis in young infants with congenital heart disease.

Journal Article (Journal Article)

BACKGROUND: We sought to describe the incidence, pathogen distribution, and mortality associated with blood culture-proven sepsis in young infants with congenital heart disease (CHD) admitted to a neonatal intensive care unit (NICU). METHODS: Cohort study of all blood cultures obtained from infants with CHD between 4 and 120 days of age cared for in 250 NICUs managed by the Pediatrix Medical Group in the United States between 1996 and 2007. RESULTS: Of 11,638 infants with CHD, 656 (6%) had 821 episodes of sepsis: a cumulative incidence of 71/1000 admissions. Gram-positive organisms were the most common cause (64%), and coagulase-negative Staphylococcus and Staphylococcus aureus were the most frequently isolated species. On multivariable regression, infants with sepsis were more likely to die compared to infants with sterile blood cultures (odds ratio [OR] = 1.53 [95% confidence interval: 1.09, 2.13]). Infants with Gram-negative bacteraemia and candidaemia were more likely to die than infants with sterile blood cultures (OR = 2.01 [1.20, 3.37], and OR = 3.18 [1.60, 6.34], respectively). CONCLUSION: Infants with CHD have a high incidence of culture-proven sepsis, especially with staphylococcal organisms. Gram-negative bacteraemia and candidaemia are strongly associated with increased mortality in this group of young infants.

Full Text

Duke Authors

Cited Authors

  • Ascher, SB; Smith, PB; Clark, RH; Cohen-Wolkowiez, M; Li, JS; Watt, K; Jacqz-Aigrain, E; Kaguelidou, F; Manzoni, P; Benjamin, DK

Published Date

  • May 2012

Published In

Volume / Issue

  • 88 Suppl 2 /

Start / End Page

  • S92 - S97

PubMed ID

  • 22633525

Pubmed Central ID

  • PMC3513769

Electronic International Standard Serial Number (EISSN)

  • 1872-6232

Digital Object Identifier (DOI)

  • 10.1016/S0378-3782(12)70025-7


  • eng

Conference Location

  • Ireland