The association of oral hydroxyurea therapy with improved cognitive functioning in sickle cell disease.


Journal Article

This study examined potential cognitive benefits of oral hydroxyurea therapy for children with sickle cell disease (SCD). Cognitive abilities of 15 children with SCD on hydroxyurea were compared to 50 other children with SCD, controlling for demographics and hematocrit. Children on hydroxyurea scored significantly higher on tests of verbal comprehension, fluid reasoning, and general cognitive ability than children not on the drug. The data therefore provide preliminary evidence of cognitive benefits of hydroxyurea. Mechanisms for this effect may be improved blood/oxygen supply to the brain or reduced fatigue and illness.

Full Text

Duke Authors

Cited Authors

  • Puffer, E; Schatz, J; Roberts, CW

Published Date

  • March 2007

Published In

Volume / Issue

  • 13 / 2

Start / End Page

  • 142 - 154

PubMed ID

  • 17364571

Pubmed Central ID

  • 17364571

Electronic International Standard Serial Number (EISSN)

  • 1744-4136

International Standard Serial Number (ISSN)

  • 0929-7049

Digital Object Identifier (DOI)

  • 10.1080/09297040600584626


  • eng