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Effect of dexmedetomidine on pulmonary artery pressure after congenital cardiac surgery: A pilot study.

Publication ,  Journal Article
Lazol, JP; Lichtenstein, SE; Jooste, EH; Shiderly, D; Kudchadker, NA; Tatum, GH; Orr, RA; Wearden, PD; Morell, VO; Munoz, RA; Chrysostomou, C
Published in: Pediatr Crit Care Med
September 2010

OBJECTIVE: To characterize the effects of dexmedetomidine on the pulmonary artery pressure in patients after congenital cardiac surgery. DESIGN: Prospective observational pilot study. SETTING: Pediatric cardiac intensive care unit at a university hospital. PATIENTS: Twenty-two patients who received dexmedetomidine after cardiothoracic surgery. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: An echocardiogram was performed at three time points: 1) baseline (T0); 2) 6 mins after dexmedetomidine loading (T1); and 3) 1 hr after initiation of dexmedetomidine infusion (T2). Transthoracic echocardiography was used to estimate pulmonary artery pressure based on tricuspid regurgitant velocity (4 x Velocity2) plus central venous pressure. Twenty-two patients aged 0.9 yrs old (interquartile range, 7.9) were enrolled at a median of 1 hr (1.5) after surgery. Dexmedetomidine loading, 0.62 microg/kg (0.5), was given in all patients followed by 0.5 microg/kg/hr (0.6) at T1 and 0.65 microg/kg/hr (0.5) at T2. None of the patients had any increase in pulmonary artery pressure. Overall, the pulmonary artery pressure decreased from 30 mm Hg (13) at T0 to 24 mm Hg (10) at T1 and 26 mm Hg (8) at T2 (p < .001). The pulmonary artery pressure/systemic systolic blood pressure ratio decreased from 33% (12) at T0 to 23% (15) at T1 and 25% (13) at T2 (p = .002). There was no difference in the left ventricular function, Fio2, oxygen %, Po2, CO2, and vasoactive agents. CONCLUSIONS: Administration of dexmedetomidine after congenital cardiac surgery was not associated with any increase in pulmonary artery pressure.

Duke Scholars

Published In

Pediatr Crit Care Med

DOI

ISSN

1529-7535

Publication Date

September 2010

Volume

11

Issue

5

Start / End Page

589 / 592

Location

United States

Related Subject Headings

  • Pulmonary Artery
  • Prospective Studies
  • Pilot Projects
  • Pediatrics
  • Male
  • Infant
  • Hypnotics and Sedatives
  • Humans
  • Heart Defects, Congenital
  • Female
 

Citation

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Lazol, J. P., Lichtenstein, S. E., Jooste, E. H., Shiderly, D., Kudchadker, N. A., Tatum, G. H., … Chrysostomou, C. (2010). Effect of dexmedetomidine on pulmonary artery pressure after congenital cardiac surgery: A pilot study. Pediatr Crit Care Med, 11(5), 589–592. https://doi.org/10.1097/PCC.0b013e3181ceae7d
Lazol, Judith P., Steven E. Lichtenstein, Edmund H. Jooste, Dana Shiderly, Nivedit A. Kudchadker, Gregory H. Tatum, Richard A. Orr, et al. “Effect of dexmedetomidine on pulmonary artery pressure after congenital cardiac surgery: A pilot study.Pediatr Crit Care Med 11, no. 5 (September 2010): 589–92. https://doi.org/10.1097/PCC.0b013e3181ceae7d.
Lazol JP, Lichtenstein SE, Jooste EH, Shiderly D, Kudchadker NA, Tatum GH, et al. Effect of dexmedetomidine on pulmonary artery pressure after congenital cardiac surgery: A pilot study. Pediatr Crit Care Med. 2010 Sep;11(5):589–92.
Lazol, Judith P., et al. “Effect of dexmedetomidine on pulmonary artery pressure after congenital cardiac surgery: A pilot study.Pediatr Crit Care Med, vol. 11, no. 5, Sept. 2010, pp. 589–92. Pubmed, doi:10.1097/PCC.0b013e3181ceae7d.
Lazol JP, Lichtenstein SE, Jooste EH, Shiderly D, Kudchadker NA, Tatum GH, Orr RA, Wearden PD, Morell VO, Munoz RA, Chrysostomou C. Effect of dexmedetomidine on pulmonary artery pressure after congenital cardiac surgery: A pilot study. Pediatr Crit Care Med. 2010 Sep;11(5):589–592.

Published In

Pediatr Crit Care Med

DOI

ISSN

1529-7535

Publication Date

September 2010

Volume

11

Issue

5

Start / End Page

589 / 592

Location

United States

Related Subject Headings

  • Pulmonary Artery
  • Prospective Studies
  • Pilot Projects
  • Pediatrics
  • Male
  • Infant
  • Hypnotics and Sedatives
  • Humans
  • Heart Defects, Congenital
  • Female