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Complications of implantable venous access devices in patients with sickle cell disease.

Publication ,  Journal Article
Shah, N; Landi, D; Shah, R; Rothman, J; De Castro, LM; Thornburg, CD
Published in: Am J Hematol
February 2012

Implantable venous access devices (VADs) are used in sickle cell disease (SCD) for patients with poor venous access to facilitate chronic blood transfusions and manage acute complications. We attempted to define the frequency of bloodstream infections (BSI) and thrombosis in adults and children with SCD and VADs. We performed a single-institution, retrospective review of VAD-associated infection and thrombosis in patients with SCD. Thirty-two patients (median age 20 years, range, 1-59) had 86 VADs placed (median, 2.7 VADs per patient, range, 1-7) with a total of 41,292 catheter days (median, 1,376 days; range, 323-3,999). Mean catheter lifespan in adults (691 days ± 123) was not significantly higher than children (614 days ± 154). A total of 66 VAD-associated BSI (1.59 infections per 1,000 catheter days) occurred in 17 of 32 (53%) patients. Children with VADs had fewer BSI (3 of 10; 30%) than adults (14 of 22; 64%, P = 0.08). 24 catheter-associated thromboses (0.49 thromboses per 1,000 catheter days) occurred in 10 of 32 (41%) of patients. Children also had fewer VAD-associated-thrombosis (1 of 10; 10%) than adults (9 of 22; 40%, P = 0.08). In conclusion, the use of VADs in SCD was linked to a significant rate of infection and thrombosis.

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Published In

Am J Hematol

DOI

EISSN

1096-8652

Publication Date

February 2012

Volume

87

Issue

2

Start / End Page

224 / 226

Location

United States

Related Subject Headings

  • Thrombosis
  • Retrospective Studies
  • Prosthesis-Related Infections
  • Mycoses
  • Middle Aged
  • Male
  • Infant
  • Immunology
  • Humans
  • Gram-Positive Bacteria
 

Citation

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Shah, N., Landi, D., Shah, R., Rothman, J., De Castro, L. M., & Thornburg, C. D. (2012). Complications of implantable venous access devices in patients with sickle cell disease. Am J Hematol, 87(2), 224–226. https://doi.org/10.1002/ajh.22230
Shah, Nirmish, Daniel Landi, Radhika Shah, Jennifer Rothman, Laura M. De Castro, and Courtney D. Thornburg. “Complications of implantable venous access devices in patients with sickle cell disease.Am J Hematol 87, no. 2 (February 2012): 224–26. https://doi.org/10.1002/ajh.22230.
Shah N, Landi D, Shah R, Rothman J, De Castro LM, Thornburg CD. Complications of implantable venous access devices in patients with sickle cell disease. Am J Hematol. 2012 Feb;87(2):224–6.
Shah, Nirmish, et al. “Complications of implantable venous access devices in patients with sickle cell disease.Am J Hematol, vol. 87, no. 2, Feb. 2012, pp. 224–26. Pubmed, doi:10.1002/ajh.22230.
Shah N, Landi D, Shah R, Rothman J, De Castro LM, Thornburg CD. Complications of implantable venous access devices in patients with sickle cell disease. Am J Hematol. 2012 Feb;87(2):224–226.
Journal cover image

Published In

Am J Hematol

DOI

EISSN

1096-8652

Publication Date

February 2012

Volume

87

Issue

2

Start / End Page

224 / 226

Location

United States

Related Subject Headings

  • Thrombosis
  • Retrospective Studies
  • Prosthesis-Related Infections
  • Mycoses
  • Middle Aged
  • Male
  • Infant
  • Immunology
  • Humans
  • Gram-Positive Bacteria