Rapamycin does not control hemophagocytic lymphohistiocytosis in LCMV-infected perforin-deficient mice.
Hemophagocytic lymphohistiocytosis (HLH) is an immunodysregulatory disorder for which more effective treatments are needed. The macrolide rapamycin has immunosuppressive properties, making it an attractive candidate for controlling the aberrant T cell activation that occurs in HLH. To investigate its therapeutic potential, we used rapamycin to treat Lymphocytic Choriomeningitis Virus (LCMV)-infected perforin-deficient (Prf1(-/-)) mice according to a well-established model of HLH. At the regimens tested, rapamycin did not improve weight loss, splenomegaly, hemophagocytosis, cytopenias, or proinflammatory cytokine production in LCMV-infected Prf1(-/-) animals. Thus, single agent rapamycin appears ineffective in treating the clinical and laboratory manifestations of LCMV-induced HLH.
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- Sirolimus
- Perforin
- Oncology & Carcinogenesis
- Mice, Knockout
- Mice, Inbred C57BL
- Mice
- Lymphohistiocytosis, Hemophagocytic
- Lymphocytic choriomeningitis virus
- Immunosuppressive Agents
- Flow Cytometry
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Sirolimus
- Perforin
- Oncology & Carcinogenesis
- Mice, Knockout
- Mice, Inbred C57BL
- Mice
- Lymphohistiocytosis, Hemophagocytic
- Lymphocytic choriomeningitis virus
- Immunosuppressive Agents
- Flow Cytometry