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Activity of neurons in monkey globus pallidus during oculomotor behavior compared with that in substantia nigra pars reticulata.

Publication ,  Journal Article
Shin, S; Sommer, MA
Published in: Journal of neurophysiology
April 2010

The basal ganglia are a subcortical assembly of nuclei involved in many aspects of behavior. Three of the nuclei have high firing rates and inhibitory influences: the substantia nigra pars reticulata (SNr), globus pallidus interna (GPi), and globus pallidus externa (GPe). The SNr contains a wide range of visual, cognitive, and motor signals that have been shown to contribute to saccadic eye movements. Our hypothesis was that GPe and GPi neurons carry similarly diverse signals during saccadic behavior. We recorded from GPe, GPi, and SNr neurons in monkeys that made memory-guided saccades and found that neurons in all three structures had increases or decreases in activity synchronized with saccade generation, visual stimulation, or reward. Comparing GPe neurons with GPi neurons, we found relatively more visual-related activity in GPe and more reward-related activity in GPi. Comparing both pallidal samples with the SNr, we found a greater resemblance between GPe and SNr neurons than that between GPi and SNr neurons. As expected from a known inhibitory projection from GPe to SNr, there was a general reversal of sign in activity modulations between the structures: bursts of activity were relatively more common in GPe and pauses more common in SNr. We analyzed the response fields of neurons in all three structures and found relatively narrow and lateralized fields early in trials (during visual and saccadic events) followed by a broadening later in trials (during reward). Our data reinforce an emerging, new consensus that the GPe and GPi, in addition to the SNr, contribute to oculomotor behavior.

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Published In

Journal of neurophysiology

DOI

EISSN

1522-1598

ISSN

0022-3077

Publication Date

April 2010

Volume

103

Issue

4

Start / End Page

1874 / 1887

Related Subject Headings

  • Substantia Nigra
  • Sensory Receptor Cells
  • Photic Stimulation
  • Oculomotor Muscles
  • Neurology & Neurosurgery
  • Motor Activity
  • Models, Animal
  • Magnetic Resonance Imaging
  • Macaca mulatta
  • Globus Pallidus
 

Citation

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Shin, S., & Sommer, M. A. (2010). Activity of neurons in monkey globus pallidus during oculomotor behavior compared with that in substantia nigra pars reticulata. Journal of Neurophysiology, 103(4), 1874–1887. https://doi.org/10.1152/jn.00101.2009
Shin, SooYoon, and Marc A. Sommer. “Activity of neurons in monkey globus pallidus during oculomotor behavior compared with that in substantia nigra pars reticulata.Journal of Neurophysiology 103, no. 4 (April 2010): 1874–87. https://doi.org/10.1152/jn.00101.2009.
Shin, SooYoon, and Marc A. Sommer. “Activity of neurons in monkey globus pallidus during oculomotor behavior compared with that in substantia nigra pars reticulata.Journal of Neurophysiology, vol. 103, no. 4, Apr. 2010, pp. 1874–87. Epmc, doi:10.1152/jn.00101.2009.

Published In

Journal of neurophysiology

DOI

EISSN

1522-1598

ISSN

0022-3077

Publication Date

April 2010

Volume

103

Issue

4

Start / End Page

1874 / 1887

Related Subject Headings

  • Substantia Nigra
  • Sensory Receptor Cells
  • Photic Stimulation
  • Oculomotor Muscles
  • Neurology & Neurosurgery
  • Motor Activity
  • Models, Animal
  • Magnetic Resonance Imaging
  • Macaca mulatta
  • Globus Pallidus