Skip to main content
Journal cover image

Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study.

Publication ,  Journal Article
Kasperaviciūte, D; Catarino, CB; Heinzen, EL; Depondt, C; Cavalleri, GL; Caboclo, LO; Tate, SK; Jamnadas-Khoda, J; Chinthapalli, K; Clayton, LMS ...
Published in: Brain
July 2010

Partial epilepsies have a substantial heritability. However, the actual genetic causes are largely unknown. In contrast to many other common diseases for which genetic association-studies have successfully revealed common variants associated with disease risk, the role of common variation in partial epilepsies has not yet been explored in a well-powered study. We undertook a genome-wide association-study to identify common variants which influence risk for epilepsy shared amongst partial epilepsy syndromes, in 3445 patients and 6935 controls of European ancestry. We did not identify any genome-wide significant association. A few single nucleotide polymorphisms may warrant further investigation. We exclude common genetic variants with effect sizes above a modest 1.3 odds ratio for a single variant as contributors to genetic susceptibility shared across the partial epilepsies. We show that, at best, common genetic variation can only have a modest role in predisposition to the partial epilepsies when considered across syndromes in Europeans. The genetic architecture of the partial epilepsies is likely to be very complex, reflecting genotypic and phenotypic heterogeneity. Larger meta-analyses are required to identify variants of smaller effect sizes (odds ratio<1.3) or syndrome-specific variants. Further, our results suggest research efforts should also be directed towards identifying the multiple rare variants likely to account for at least part of the heritability of the partial epilepsies. Data emerging from genome-wide association-studies will be valuable during the next serious challenge of interpreting all the genetic variation emerging from whole-genome sequencing studies.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Brain

DOI

EISSN

1460-2156

Publication Date

July 2010

Volume

133

Issue

Pt 7

Start / End Page

2136 / 2147

Location

England

Related Subject Headings

  • Syndrome
  • Polymorphism, Single Nucleotide
  • Neurology & Neurosurgery
  • Male
  • Internationality
  • Humans
  • Genome-Wide Association Study
  • Genetic Variation
  • Genetic Predisposition to Disease
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kasperaviciūte, D., Catarino, C. B., Heinzen, E. L., Depondt, C., Cavalleri, G. L., Caboclo, L. O., … Sisodiya, S. M. (2010). Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study. Brain, 133(Pt 7), 2136–2147. https://doi.org/10.1093/brain/awq130
Kasperaviciūte, Dalia, Claudia B. Catarino, Erin L. Heinzen, Chantal Depondt, Gianpiero L. Cavalleri, Luis O. Caboclo, Sarah K. Tate, et al. “Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study.Brain 133, no. Pt 7 (July 2010): 2136–47. https://doi.org/10.1093/brain/awq130.
Kasperaviciūte D, Catarino CB, Heinzen EL, Depondt C, Cavalleri GL, Caboclo LO, et al. Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study. Brain. 2010 Jul;133(Pt 7):2136–47.
Kasperaviciūte, Dalia, et al. “Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study.Brain, vol. 133, no. Pt 7, July 2010, pp. 2136–47. Pubmed, doi:10.1093/brain/awq130.
Kasperaviciūte D, Catarino CB, Heinzen EL, Depondt C, Cavalleri GL, Caboclo LO, Tate SK, Jamnadas-Khoda J, Chinthapalli K, Clayton LMS, Shianna KV, Radtke RA, Mikati MA, Gallentine WB, Husain AM, Alhusaini S, Leppert D, Middleton LT, Gibson RA, Johnson MR, Matthews PM, Hosford D, Heuser K, Amos L, Ortega M, Zumsteg D, Wieser H-G, Steinhoff BJ, Krämer G, Hansen J, Dorn T, Kantanen A-M, Gjerstad L, Peuralinna T, Hernandez DG, Eriksson KJ, Kälviäinen RK, Doherty CP, Wood NW, Pandolfo M, Duncan JS, Sander JW, Delanty N, Goldstein DB, Sisodiya SM. Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study. Brain. 2010 Jul;133(Pt 7):2136–2147.
Journal cover image

Published In

Brain

DOI

EISSN

1460-2156

Publication Date

July 2010

Volume

133

Issue

Pt 7

Start / End Page

2136 / 2147

Location

England

Related Subject Headings

  • Syndrome
  • Polymorphism, Single Nucleotide
  • Neurology & Neurosurgery
  • Male
  • Internationality
  • Humans
  • Genome-Wide Association Study
  • Genetic Variation
  • Genetic Predisposition to Disease
  • Female