Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study.

Published

Journal Article

Partial epilepsies have a substantial heritability. However, the actual genetic causes are largely unknown. In contrast to many other common diseases for which genetic association-studies have successfully revealed common variants associated with disease risk, the role of common variation in partial epilepsies has not yet been explored in a well-powered study. We undertook a genome-wide association-study to identify common variants which influence risk for epilepsy shared amongst partial epilepsy syndromes, in 3445 patients and 6935 controls of European ancestry. We did not identify any genome-wide significant association. A few single nucleotide polymorphisms may warrant further investigation. We exclude common genetic variants with effect sizes above a modest 1.3 odds ratio for a single variant as contributors to genetic susceptibility shared across the partial epilepsies. We show that, at best, common genetic variation can only have a modest role in predisposition to the partial epilepsies when considered across syndromes in Europeans. The genetic architecture of the partial epilepsies is likely to be very complex, reflecting genotypic and phenotypic heterogeneity. Larger meta-analyses are required to identify variants of smaller effect sizes (odds ratio<1.3) or syndrome-specific variants. Further, our results suggest research efforts should also be directed towards identifying the multiple rare variants likely to account for at least part of the heritability of the partial epilepsies. Data emerging from genome-wide association-studies will be valuable during the next serious challenge of interpreting all the genetic variation emerging from whole-genome sequencing studies.

Full Text

Duke Authors

Cited Authors

  • KasperaviciĆ«te, D; Catarino, CB; Heinzen, EL; Depondt, C; Cavalleri, GL; Caboclo, LO; Tate, SK; Jamnadas-Khoda, J; Chinthapalli, K; Clayton, LMS; Shianna, KV; Radtke, RA; Mikati, MA; Gallentine, WB; Husain, AM; Alhusaini, S; Leppert, D; Middleton, LT; Gibson, RA; Johnson, MR; Matthews, PM; Hosford, D; Heuser, K; Amos, L; Ortega, M; Zumsteg, D; Wieser, H-G; Steinhoff, BJ; Krämer, G; Hansen, J; Dorn, T; Kantanen, A-M; Gjerstad, L; Peuralinna, T; Hernandez, DG; Eriksson, KJ; Kälviäinen, RK; Doherty, CP; Wood, NW; Pandolfo, M; Duncan, JS; Sander, JW; Delanty, N; Goldstein, DB; Sisodiya, SM

Published Date

  • July 2010

Published In

Volume / Issue

  • 133 / Pt 7

Start / End Page

  • 2136 - 2147

PubMed ID

  • 20522523

Pubmed Central ID

  • 20522523

Electronic International Standard Serial Number (EISSN)

  • 1460-2156

International Standard Serial Number (ISSN)

  • 0006-8950

Digital Object Identifier (DOI)

  • 10.1093/brain/awq130

Language

  • eng