Skip to main content
Journal cover image

Structural connectivity of the frontal lobe in children with drug-resistant partial epilepsy.

Publication ,  Journal Article
Holt, RL; Provenzale, JM; Veerapandiyan, A; Moon, W-J; De Bellis, MD; Leonard, S; Gallentine, WB; Grant, GA; Egger, H; Song, AW; Mikati, MA
Published in: Epilepsy Behav
May 2011

The superior longitudinal fasciculus (SLF) II and cingulum are two white matter tracts important for attention and other frontal lobe functions. These functions are often disturbed in children with drug-resistant (DR) partial epilepsy, even when no abnormalities are seen on conventional MRI. We set out to determine whether abnormalities in these structures might be depicted on diffusion tensor imaging (DTI) studies in the absence of abnormalities on conventional MRI. We compared the DTI findings of 12 children with DR partial epilepsy with those of 12 age- and gender-matched controls. We found that the SLF II fractional anisotropy (FA) values of the patients were significantly lower than those of the controls (means: 0.398±0.057 and 0.443±0.059, respectively, P=0.002). Similarly, apparent diffusion coefficient (ADC) and parallel diffusivity values for SLF II were also significantly lower in the patients. There were no differences in the FA and ADC values of the cingulum. Our findings are consistent with abnormal structural connectivity of the frontal lobe in children with DR partial epilepsy and provide a possible explanation for the previously reported functional abnormalities related to the SLF II in these patients.

Duke Scholars

Published In

Epilepsy Behav

DOI

EISSN

1525-5069

Publication Date

May 2011

Volume

21

Issue

1

Start / End Page

65 / 70

Location

United States

Related Subject Headings

  • Video Recording
  • Neurology & Neurosurgery
  • Male
  • Humans
  • Frontal Lobe
  • Female
  • Epilepsies, Partial
  • Electroencephalography
  • Drug Resistance
  • Diffusion Magnetic Resonance Imaging
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Holt, R. L., Provenzale, J. M., Veerapandiyan, A., Moon, W.-J., De Bellis, M. D., Leonard, S., … Mikati, M. A. (2011). Structural connectivity of the frontal lobe in children with drug-resistant partial epilepsy. Epilepsy Behav, 21(1), 65–70. https://doi.org/10.1016/j.yebeh.2011.03.016
Holt, Rebecca L., James M. Provenzale, Aravindhan Veerapandiyan, Won-Jin Moon, Michael D. De Bellis, Soren Leonard, William B. Gallentine, et al. “Structural connectivity of the frontal lobe in children with drug-resistant partial epilepsy.Epilepsy Behav 21, no. 1 (May 2011): 65–70. https://doi.org/10.1016/j.yebeh.2011.03.016.
Holt RL, Provenzale JM, Veerapandiyan A, Moon W-J, De Bellis MD, Leonard S, et al. Structural connectivity of the frontal lobe in children with drug-resistant partial epilepsy. Epilepsy Behav. 2011 May;21(1):65–70.
Holt, Rebecca L., et al. “Structural connectivity of the frontal lobe in children with drug-resistant partial epilepsy.Epilepsy Behav, vol. 21, no. 1, May 2011, pp. 65–70. Pubmed, doi:10.1016/j.yebeh.2011.03.016.
Holt RL, Provenzale JM, Veerapandiyan A, Moon W-J, De Bellis MD, Leonard S, Gallentine WB, Grant GA, Egger H, Song AW, Mikati MA. Structural connectivity of the frontal lobe in children with drug-resistant partial epilepsy. Epilepsy Behav. 2011 May;21(1):65–70.
Journal cover image

Published In

Epilepsy Behav

DOI

EISSN

1525-5069

Publication Date

May 2011

Volume

21

Issue

1

Start / End Page

65 / 70

Location

United States

Related Subject Headings

  • Video Recording
  • Neurology & Neurosurgery
  • Male
  • Humans
  • Frontal Lobe
  • Female
  • Epilepsies, Partial
  • Electroencephalography
  • Drug Resistance
  • Diffusion Magnetic Resonance Imaging