Potential neuroprotective effects of continuous topiramate therapy in the developing brain.

Journal Article (Journal Article)

Because antiepileptic drug therapy is usually given chronically with resulting concerns about long-term neurotoxicity, and because short-term topiramate (TPM) therapy has been reported to be neuroprotective against the effects of acute hypoxia, we investigated the long-term effects of continuous TPM therapy during early stages of development. Four groups of rat pups were studied: two sham manipulated normoxia groups and two acute hypoxia groups (at postnatal day [P] 10 down to 4% O(2)), each injected intraperitoneally daily with either vehicle or TPM (30 mg/kg) from P0 to P21. TPM therapy prevented hypoxia-induced long-term (P81) memory impairment (Morris water maze) as well as aggressivity (handling test). The hypoxia group receiving TPM also showed a trend toward reduced CA1 hippocampal cell loss. The aforementioned TPM therapy had no long-term deleterious effects on memory, hyperactivity, or CA1 cell counts in the TPM normoxia group as compared with normal controls.

Full Text

Duke Authors

Cited Authors

  • Mikati, MA; Daderian, R; Zeinieh, M; Leonard, AS; Azzam, D; Kurdi, R

Published Date

  • April 2011

Published In

Volume / Issue

  • 20 / 4

Start / End Page

  • 597 - 601

PubMed ID

  • 21450530

Electronic International Standard Serial Number (EISSN)

  • 1525-5069

Digital Object Identifier (DOI)

  • 10.1016/j.yebeh.2010.12.011


  • eng

Conference Location

  • United States