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Diminishment of respiratory sinus arrhythmia foreshadows doxorubicin-induced cardiomyopathy.

Publication ,  Journal Article
Hrushesky, WJ; Fader, DJ; Berestka, JS; Sommer, M; Hayes, J; Cope, FO
Published in: Circulation
August 1991

The development of a microcomputer-based device permits quick, simple, and noninvasive quantification of the respiratory sinus arrhythmia (RSA) during quiet breathing.We prospectively and serially measured the radionuclide left ventricular ejection fraction and the RSA amplitude in 34 cancer patients receiving up to nine monthly bolus treatments with doxorubicin hydrochloride (60 mg/m2). Of the eight patients who ultimately developed symptomatic doxorubicin-induced congestive heart failure, seven (87.5%) demonstrated a significant decline in RSA amplitude; five of 26 subjects without clinical symptoms of cardiotoxicity (19.2%) showed a similar RSA amplitude decline. On average, significant RSA amplitude decline occurred 3 months before the last planned doxorubicin dose in patients destined to develop clinical congestive heart failure.Overall, RSA amplitude abnormality proved to be a more specific predictor of clinically significant congestive heart failure than did serial resting radionuclide ejection fractions.

Duke Scholars

Published In

Circulation

DOI

EISSN

1524-4539

ISSN

0009-7322

Publication Date

August 1991

Volume

84

Issue

2

Start / End Page

697 / 707

Related Subject Headings

  • Vagus Nerve
  • Stroke Volume
  • Sinoatrial Node
  • Middle Aged
  • Male
  • Humans
  • Heart Rate
  • Heart Failure
  • Forecasting
  • Female
 

Citation

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MLA
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Hrushesky, W. J., Fader, D. J., Berestka, J. S., Sommer, M., Hayes, J., & Cope, F. O. (1991). Diminishment of respiratory sinus arrhythmia foreshadows doxorubicin-induced cardiomyopathy. Circulation, 84(2), 697–707. https://doi.org/10.1161/01.cir.84.2.697
Hrushesky, W. J., D. J. Fader, J. S. Berestka, M. Sommer, J. Hayes, and F. O. Cope. “Diminishment of respiratory sinus arrhythmia foreshadows doxorubicin-induced cardiomyopathy.Circulation 84, no. 2 (August 1991): 697–707. https://doi.org/10.1161/01.cir.84.2.697.
Hrushesky WJ, Fader DJ, Berestka JS, Sommer M, Hayes J, Cope FO. Diminishment of respiratory sinus arrhythmia foreshadows doxorubicin-induced cardiomyopathy. Circulation. 1991 Aug;84(2):697–707.
Hrushesky, W. J., et al. “Diminishment of respiratory sinus arrhythmia foreshadows doxorubicin-induced cardiomyopathy.Circulation, vol. 84, no. 2, Aug. 1991, pp. 697–707. Epmc, doi:10.1161/01.cir.84.2.697.
Hrushesky WJ, Fader DJ, Berestka JS, Sommer M, Hayes J, Cope FO. Diminishment of respiratory sinus arrhythmia foreshadows doxorubicin-induced cardiomyopathy. Circulation. 1991 Aug;84(2):697–707.

Published In

Circulation

DOI

EISSN

1524-4539

ISSN

0009-7322

Publication Date

August 1991

Volume

84

Issue

2

Start / End Page

697 / 707

Related Subject Headings

  • Vagus Nerve
  • Stroke Volume
  • Sinoatrial Node
  • Middle Aged
  • Male
  • Humans
  • Heart Rate
  • Heart Failure
  • Forecasting
  • Female