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Assessing the performance of the Birmingham Vasculitis Activity Score at diagnosis for children with antineutrophil cytoplasmic antibody-associated vasculitis in A Registry for Childhood Vasculitis (ARChiVe).

Publication ,  Journal Article
Morishita, K; Li, SC; Muscal, E; Spalding, S; Guzman, J; Uribe, A; Abramson, L; Baszis, K; Benseler, S; Bowyer, S; Campillo, S; Chira, P ...
Published in: J Rheumatol
May 2012

OBJECTIVE: There are no validated tools for measuring disease activity in pediatric vasculitis. The Birmingham Vasculitis Activity Score (BVAS) is a valid disease activity tool in adult vasculitis. Version 3 (BVAS v.3) correlates well with physician's global assessment (PGA), treatment decision, and C-reactive protein in adults. The utility of BVAS v.3 in pediatric vasculitis is not known. We assessed the association of BVAS v.3 scores with PGA, treatment decision, and erythrocyte sedimentation rate (ESR) at diagnosis in pediatric antineutrophil cytoplasmic antibody-associated vasculitis (AAV). METHODS: Children with AAV diagnosed between 2004 and 2010 at all ARChiVe centers were eligible. BVAS v.3 scores were calculated with a standardized online tool (www.vasculitis.org). Spearman's rank correlation coefficient (r(s)) was used to test the strength of association between BVAS v.3 and PGA, treatment decision, and ESR. RESULTS: A total of 152 patients were included. The physician diagnosis of these patients was predominantly granulomatosis with polyangiitis (n = 99). The median BVAS v.3 score was 18.0 (range 0-40). The BVAS v.3 correlations were r(s) = 0.379 (95% CI 0.233 to 0.509) with PGA, r(s) = 0.521 (95% CI 0.393 to 0.629) with treatment decision, and r(s) = 0.403 (95% CI 0.253 to 0.533) with ESR. CONCLUSION: Applied to children with AAV, BVAS v.3 had a weak correlation with PGA and moderate correlation with both ESR and treatment decision. Prospective evaluation of BVAS v.3 and/or pediatric-specific modifications to BVAS v.3 may be required before it can be formalized as a disease activity assessment tool in pediatric AAV.

Duke Scholars

Published In

J Rheumatol

DOI

EISSN

1499-2752

Publication Date

May 2012

Volume

39

Issue

5

Start / End Page

1088 / 1094

Location

Canada

Related Subject Headings

  • Vasculitis
  • Severity of Illness Index
  • Rheumatology
  • Retrospective Studies
  • Reproducibility of Results
  • Registries
  • Pediatrics
  • Male
  • Humans
  • Granulomatosis with Polyangiitis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Morishita, K., Li, S. C., Muscal, E., Spalding, S., Guzman, J., Uribe, A., … ARChiVe Investigators Network, . (2012). Assessing the performance of the Birmingham Vasculitis Activity Score at diagnosis for children with antineutrophil cytoplasmic antibody-associated vasculitis in A Registry for Childhood Vasculitis (ARChiVe). J Rheumatol, 39(5), 1088–1094. https://doi.org/10.3899/jrheum.111030
Morishita, Kimberly, Suzanne C. Li, Eyal Muscal, Steven Spalding, Jaime Guzman, America Uribe, Leslie Abramson, et al. “Assessing the performance of the Birmingham Vasculitis Activity Score at diagnosis for children with antineutrophil cytoplasmic antibody-associated vasculitis in A Registry for Childhood Vasculitis (ARChiVe).J Rheumatol 39, no. 5 (May 2012): 1088–94. https://doi.org/10.3899/jrheum.111030.
Morishita K, Li SC, Muscal E, Spalding S, Guzman J, Uribe A, Abramson L, Baszis K, Benseler S, Bowyer S, Campillo S, Chira P, Hersh AO, Higgins G, Eberhard A, Ede K, Imundo L, Jung L, Kim S, Kingsbury DJ, Klein-Gitelman M, Lawson EF, Lovell DJ, Mason T, McCurdy D, Nanda K, Nassi L, O’Neil KM, Rabinovich E, Ramsey SE, Reiff A, Rosenkranz M, Schikler K, Stevens A, Wahezi D, Cabral DA, ARChiVe Investigators Network. Assessing the performance of the Birmingham Vasculitis Activity Score at diagnosis for children with antineutrophil cytoplasmic antibody-associated vasculitis in A Registry for Childhood Vasculitis (ARChiVe). J Rheumatol. 2012 May;39(5):1088–1094.

Published In

J Rheumatol

DOI

EISSN

1499-2752

Publication Date

May 2012

Volume

39

Issue

5

Start / End Page

1088 / 1094

Location

Canada

Related Subject Headings

  • Vasculitis
  • Severity of Illness Index
  • Rheumatology
  • Retrospective Studies
  • Reproducibility of Results
  • Registries
  • Pediatrics
  • Male
  • Humans
  • Granulomatosis with Polyangiitis