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Hepatocellular MR contrast agents: enhancement characteristics of liver parenchyma and portal vein after administration of gadoxetic acid in comparison to gadobenate dimeglumine.

Publication ,  Journal Article
Feuerlein, S; Gupta, RT; Boll, DT; Merkle, EM
Published in: Eur J Radiol
September 2012

PURPOSE: To investigate the enhancement characteristics of liver parenchyma and portal vein as well as the portal vein-to liver contrast in Gd-EOB-DTPA- and Gd-BOPTA-enhanced abdominal MRI. MATERIALS AND METHODS: The local institutional review board approved this retrospective study. A total of 70 patients (30 female, 40 male) without relevant liver disease underwent either Gd-EOB-DTPA-enhanced (35 patients, dose 0.025 mmol/kg) or Gd-BOPTA-enhanced (35 patients, dose 0.1 mmol/kg) abdominal MRI. Signal-to-noise ratios (SNR) for the portal vein and the liver as well as portal vein-to-liver contrast-to-noise ratios (CNR) were calculated for three consecutive arterial phases, one portal venous phase and one delayed imaging phase. RESULTS: The liver SNR showed higher values for the Gd-BOPTA group in the arterial and portal venous phases (statistically significant for the second and third arterial phase), while the liver SNR in the delayed phase was higher for the Gd-EOB-DTPA group. The portal venous SNR as well as the portal vein-to-liver CNR was higher in the Gd-BOPTA group in all imaging phases (statistically significant in all phases except for the first arterial phase). CONCLUSION: The enhancement of liver parenchyma and portal vein as well as the portal vein-to-liver contrast in the arterial and portal venous imaging phases were higher for patients receiving Gd-BOPTA compared with Gd-EOB-DTPA at the respective recommended doses. Gd-BOPTA might therefore enable better evaluation of the portal vein.

Duke Scholars

Published In

Eur J Radiol

DOI

EISSN

1872-7727

Publication Date

September 2012

Volume

81

Issue

9

Start / End Page

2037 / 2041

Location

Ireland

Related Subject Headings

  • Sensitivity and Specificity
  • Reproducibility of Results
  • Portal Vein
  • Organometallic Compounds
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Meglumine
  • Male
  • Magnetic Resonance Imaging
  • Liver Diseases
 

Citation

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Feuerlein, S., Gupta, R. T., Boll, D. T., & Merkle, E. M. (2012). Hepatocellular MR contrast agents: enhancement characteristics of liver parenchyma and portal vein after administration of gadoxetic acid in comparison to gadobenate dimeglumine. Eur J Radiol, 81(9), 2037–2041. https://doi.org/10.1016/j.ejrad.2011.06.014
Feuerlein, Sebastian, Rajan T. Gupta, Daniel T. Boll, and Elmar M. Merkle. “Hepatocellular MR contrast agents: enhancement characteristics of liver parenchyma and portal vein after administration of gadoxetic acid in comparison to gadobenate dimeglumine.Eur J Radiol 81, no. 9 (September 2012): 2037–41. https://doi.org/10.1016/j.ejrad.2011.06.014.
Feuerlein, Sebastian, et al. “Hepatocellular MR contrast agents: enhancement characteristics of liver parenchyma and portal vein after administration of gadoxetic acid in comparison to gadobenate dimeglumine.Eur J Radiol, vol. 81, no. 9, Sept. 2012, pp. 2037–41. Pubmed, doi:10.1016/j.ejrad.2011.06.014.
Journal cover image

Published In

Eur J Radiol

DOI

EISSN

1872-7727

Publication Date

September 2012

Volume

81

Issue

9

Start / End Page

2037 / 2041

Location

Ireland

Related Subject Headings

  • Sensitivity and Specificity
  • Reproducibility of Results
  • Portal Vein
  • Organometallic Compounds
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Meglumine
  • Male
  • Magnetic Resonance Imaging
  • Liver Diseases