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Liver MRI in the hepatocyte phase with gadolinium-EOB-DTPA: does increasing the flip angle improve conspicuity and detection rate of hypointense lesions?

Publication ,  Journal Article
Bashir, MR; Husarik, DB; Ziemlewicz, TJ; Gupta, RT; Boll, DT; Merkle, EM
Published in: J Magn Reson Imaging
March 2012

PURPOSE: To compare conspicuity and detection rate of hypointense lesions on T1-weighted (T1w) gradient echo (GRE) sequences with low and high flip angles (FA) in hepatocyte phase magnetic resonance imaging (MRI) using gadoxetate disodium. MATERIALS AND METHODS: This Health Insurance Portability and Accountability Act (HIPAA)-compliant study was Institutional Review Board (IRB)-approved. The study population consisted of patients with hypointense liver lesions undergoing MRI with gadoxetate disodium, with hepatocyte-phase fat suppressed 3D T1w GRE sequences at both low (10-12°) and high (30-35°) FA. Contrast-to-noise ratios (CNRs) were calculated for liver parenchyma vs. large lesions and common bile duct (CBD) vs. liver. Three radiologists each assigned a conspicuity score (CS) for each lesion detected at low or high FA. Paired Student's t-tests compared the lesion detection (LD) rate using only the hepatocyte phase data set compared with the entire MRI examination, and CS for low and high FA. RESULTS: In all, 57 large and 70 small lesions were identified in 18 patients. Average LD and CS were significantly greater at high FA versus low FA overall (LD 89.0% vs. 79.5%; CS 2.8 vs. 2.2; P < 0.05) and for small lesions (81.4% vs. 65.7%; 2.5 vs. 1.8; P < 0.05). Average liver-to-lesion CNR for large lesions and CBD-to-liver CNR was significantly greater at high FA (P < 0.05). CONCLUSION: Increasing the FA in hepatocyte phase MRI with gadoxetate disodium improves hypointense lesion detection and conspicuity, particularly for small lesions.

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Published In

J Magn Reson Imaging

DOI

EISSN

1522-2586

Publication Date

March 2012

Volume

35

Issue

3

Start / End Page

611 / 616

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Liver Diseases
  • Image Enhancement
  • Humans
  • Hepatocytes
  • Gadolinium DTPA
 

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Bashir, M. R., Husarik, D. B., Ziemlewicz, T. J., Gupta, R. T., Boll, D. T., & Merkle, E. M. (2012). Liver MRI in the hepatocyte phase with gadolinium-EOB-DTPA: does increasing the flip angle improve conspicuity and detection rate of hypointense lesions? J Magn Reson Imaging, 35(3), 611–616. https://doi.org/10.1002/jmri.22850
Bashir, Mustafa R., Daniela B. Husarik, Tim J. Ziemlewicz, Rajan T. Gupta, Daniel T. Boll, and Elmar M. Merkle. “Liver MRI in the hepatocyte phase with gadolinium-EOB-DTPA: does increasing the flip angle improve conspicuity and detection rate of hypointense lesions?J Magn Reson Imaging 35, no. 3 (March 2012): 611–16. https://doi.org/10.1002/jmri.22850.
Bashir MR, Husarik DB, Ziemlewicz TJ, Gupta RT, Boll DT, Merkle EM. Liver MRI in the hepatocyte phase with gadolinium-EOB-DTPA: does increasing the flip angle improve conspicuity and detection rate of hypointense lesions? J Magn Reson Imaging. 2012 Mar;35(3):611–6.
Bashir, Mustafa R., et al. “Liver MRI in the hepatocyte phase with gadolinium-EOB-DTPA: does increasing the flip angle improve conspicuity and detection rate of hypointense lesions?J Magn Reson Imaging, vol. 35, no. 3, Mar. 2012, pp. 611–16. Pubmed, doi:10.1002/jmri.22850.
Bashir MR, Husarik DB, Ziemlewicz TJ, Gupta RT, Boll DT, Merkle EM. Liver MRI in the hepatocyte phase with gadolinium-EOB-DTPA: does increasing the flip angle improve conspicuity and detection rate of hypointense lesions? J Magn Reson Imaging. 2012 Mar;35(3):611–616.
Journal cover image

Published In

J Magn Reson Imaging

DOI

EISSN

1522-2586

Publication Date

March 2012

Volume

35

Issue

3

Start / End Page

611 / 616

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Liver Diseases
  • Image Enhancement
  • Humans
  • Hepatocytes
  • Gadolinium DTPA