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The effects of Brief Behavioral Activation Therapy for Depression on cognitive control in affective contexts: An fMRI investigation.

Publication ,  Journal Article
Dichter, GS; Felder, JN; Smoski, MJ
Published in: J Affect Disord
October 2010

BACKGROUND: Unipolar major depressive disorder (MDD) is characterized by impaired cognitive control in affective contexts, but the potential for psychotherapy to affect the neural correlates of these functions has not been evaluated. METHOD: Twelve adults with and 15 adults without MDD participated in two identical functional magnetic resonance imaging (fMRI) scans that utilized a task requiring cognitive control in both sad and neutral contexts. Between scans, MDD outpatients received Behavioral Activation Therapy for Depression, a psychotherapy modality designed to increase engagement with positive stimuli and reduce avoidance behaviors. RESULTS: Seventy-five percent of adults with MDD were treatment responders, achieving post-treatment Hamilton Rating Scale for Depression score of six or below. Consistent with predictions, psychotherapy resulted in decreased activation in response to cognitive control stimuli presented within a sad context in prefrontal structures, including the paracingulate gyrus, the right orbital frontal cortex, and the right frontal pole. Furthermore, the magnitude of pretreatment activation in the paracingulate gyrus cluster responsive to psychotherapy predicted the magnitude of depressive symptom change after psychotherapy. LIMITATIONS: Replication with larger samples is needed, as are follow-up studies that involve placebo control groups, wait-list control groups, and alternative forms of antidepressant intervention. CONCLUSIONS: Behavioral Activation Therapy for Depression improves depressive symptoms and concomitantly influences brain systems mediating cognitive control in affective contexts.

Duke Scholars

Published In

J Affect Disord

DOI

EISSN

1573-2517

Publication Date

October 2010

Volume

126

Issue

1-2

Start / End Page

236 / 244

Location

Netherlands

Related Subject Headings

  • Psychiatry
  • Psychiatric Status Rating Scales
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Female
  • Depressive Disorder, Major
  • Cognitive Behavioral Therapy
  • Cognition
  • Case-Control Studies
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Dichter, G. S., Felder, J. N., & Smoski, M. J. (2010). The effects of Brief Behavioral Activation Therapy for Depression on cognitive control in affective contexts: An fMRI investigation. J Affect Disord, 126(1–2), 236–244. https://doi.org/10.1016/j.jad.2010.03.022
Dichter, Gabriel S., Jennifer N. Felder, and Moria J. Smoski. “The effects of Brief Behavioral Activation Therapy for Depression on cognitive control in affective contexts: An fMRI investigation.J Affect Disord 126, no. 1–2 (October 2010): 236–44. https://doi.org/10.1016/j.jad.2010.03.022.
Dichter, Gabriel S., et al. “The effects of Brief Behavioral Activation Therapy for Depression on cognitive control in affective contexts: An fMRI investigation.J Affect Disord, vol. 126, no. 1–2, Oct. 2010, pp. 236–44. Pubmed, doi:10.1016/j.jad.2010.03.022.
Journal cover image

Published In

J Affect Disord

DOI

EISSN

1573-2517

Publication Date

October 2010

Volume

126

Issue

1-2

Start / End Page

236 / 244

Location

Netherlands

Related Subject Headings

  • Psychiatry
  • Psychiatric Status Rating Scales
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Female
  • Depressive Disorder, Major
  • Cognitive Behavioral Therapy
  • Cognition
  • Case-Control Studies