Clorgyline and deprenyl attenuate striatal malonate and 3-nitropropionic acid lesions.

Journal Article (Journal Article)

We have previously shown that dopamine depletion reduces striatal damage elicited by the mitochondrial neurotoxins malonate and 3-nitropropionic acid (3NP). Metabolism of dopamine by monoamine oxidase results in the formation of hydrogen peroxide, which may mediate dopamine toxicity. In this study, administration of the monoamine oxidase inhibitors clorgyline and deprenyl resulted in a 42% and 75% reduction in lesion volumes in malonate- and 3NP-treated animals, respectively, compared to controls.

Full Text

Duke Authors

Cited Authors

  • Maragos, WF; Tillman, PA; Chesnut, MD; Jakel, RJ

Published Date

  • July 10, 1999

Published In

Volume / Issue

  • 834 / 1-2

Start / End Page

  • 168 - 172

PubMed ID

  • 10407109

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/s0006-8993(99)01487-0

Language

  • eng

Conference Location

  • Netherlands