Neuronal cell death in Huntington's disease: a potential role for dopamine.

Published

Journal Article (Review)

Huntington's disease is an inherited neurodegenerative disorder, the cause of which is unknown. Excitotoxicity, mitochondrial dysfunction and oxidative stress are all likely to contribute to the striatal cell death that occurs in this disorder. There are accumulating data indicating that under specific circumstances, dopamine, which occurs in high concentrations in the basal ganglia, might be neurotoxic. In this article, the current models used to study Huntington's disease are reviewed and the recent findings that implicate dopamine in the pathophysiology of this progressive disorder are discussed. Although many questions remain unanswered, the dopaminergic system could contribute to striatal vulnerability in Huntington's disease and provide a novel avenue for the development of new therapies.

Full Text

Duke Authors

Cited Authors

  • Jakel, RJ; Maragos, WF

Published Date

  • June 2000

Published In

Volume / Issue

  • 23 / 6

Start / End Page

  • 239 - 245

PubMed ID

  • 10838590

Pubmed Central ID

  • 10838590

Electronic International Standard Serial Number (EISSN)

  • 1878-108X

International Standard Serial Number (ISSN)

  • 0166-2236

Digital Object Identifier (DOI)

  • 10.1016/s0166-2236(00)01568-x

Language

  • eng