Org OD 14 and the endometrium.


Journal Article

Long-term therapy with (7 alpha,17 alpha)-17-hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one (Org OD 14; tibolone, Livial) has no influence on the endometrium in post-menopausal women. This was concluded from endometrial biopsies taken from 39 post-menopausal women treated with 2.5 mg/day for periods of from 3 months to 5 years 11 months at three centres. These results accord with the data published so far on 129 women who have been treated for up to 2 years. A review of the data relating to a total of 168 patients treated with Org OD 14 is presented. The endometrial pattern observed at the start of therapy showed no change during treatment in 90% of patients. In 15 cases slight proliferation was apparent after treatment, this being a similar pattern to that seen in the initial days of a normal cycle. In a considerable number of patients no tissue could be obtained, indicating an atrophic pattern. The picture following Org OD 14 therapy was the same as that observed in untreated normal post-menopausal women.

Full Text

Cited Authors

  • Genazzani, AR; Benedek-Jaszmann, LJ; Hart, DM; Andolsek, L; Kicovic, PM; Tax, L

Published Date

  • September 1, 1991

Published In

Volume / Issue

  • 13 / 3

Start / End Page

  • 243 - 251

PubMed ID

  • 1943832

Pubmed Central ID

  • 1943832

Electronic International Standard Serial Number (EISSN)

  • 1873-4111

International Standard Serial Number (ISSN)

  • 0378-5122

Digital Object Identifier (DOI)

  • 10.1016/0378-5122(91)90199-z


  • eng