Indoor environmental determinants of lung function in children.

Using pulmonary function and family respiratory questionnaire data for 16,689 white children 6 to 13 yr of age from 7 geographic areas, the investigators examined the effect of several environmental and other factors on performance, in a standard test of breathing. As expected, FEV0.75 was correlated most strongly with age, height, and sex. A dose-response relationship was observed with maternal smoking habits and explained 0.1% of the variance. No effect caused by the father's smoking habits was observed. A decrease (p = 0.0524) in FEV among older girls was associated with the presence of a gas cooking stove in the home. Although the statistical significance of the decreases was largely attributable to the size of the sample, the decreases in FEV, even though small, were thought to be biologically significant.

Duke Scholars

Author Victor Hasselblad Biostatistics & Bioinformatics, Division of Biostatistics