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Relations of a marker of endothelial activation (s-VCAM) to function and mortality in community-dwelling older adults.

Publication ,  Journal Article
Huffman, KM; Pieper, CF; Kraus, VB; Kraus, WE; Fillenbaum, GG; Cohen, HJ
Published in: J Gerontol A Biol Sci Med Sci
December 2011

BACKGROUND: We wished to determine if a marker of endothelial dysfunction/activation soluble vascular cell adhesion molecule (s-VCAM)-was related to functional status and mortality in community-dwelling older adults independent of the known effects of markers of inflammation and coagulation. METHODS: Data came from the third and fourth in-person waves of the Duke Established Populations for Epidemiologic Studies of the Elderly. Participants (aged ≥ 71 years) had participated in a blood draw (N = 1,551) from which concentrations of s-VCAM, interleukin-6, and D-dimer were determined. Information was gathered in-person on demographics, health behaviors, chronic health conditions, and functional status (Katz, Rosow-Breslau, Nagi). Death was determined through the National Death Index. Multivariable regression analysis was used to examine the adjusted association of s-VCAM with functional status; Cox proportional hazards models ascertained hazard of mortality. RESULTS: Controlled analyses indicated that cross-sectionally, but not longitudinally (4 years later), greater s-VCAM concentrations were associated with poorer function as measured by the Katz and Rosow-Breslau scales (p < .05 for both), independent of interleukin-6 and D-dimer. In controlled analyses, s-VCAM (p = .002), D-dimer (p = .008), and interleukin-6 (p = .01) were independently related to 4-year mortality; 1 SD increase in log concentration conferred 1.2-, 1.1-, and 1.2-fold increases in mortality, respectively. The greatest hazard of mortality was observed within the first year after measurement. s-VCAM concentrations were not predictive of 15-year mortality. CONCLUSIONS: Independent of inflammation and coagulation markers, endothelial dysfunction serves as a marker of, and potentially contributes causally to, poor function and death in community-dwelling older adults.

Duke Scholars

Published In

J Gerontol A Biol Sci Med Sci

DOI

EISSN

1758-535X

Publication Date

December 2011

Volume

66

Issue

12

Start / End Page

1369 / 1375

Location

United States

Related Subject Headings

  • Vascular Cell Adhesion Molecule-1
  • Solubility
  • Residence Characteristics
  • North Carolina
  • Multivariate Analysis
  • Mortality
  • Male
  • Longitudinal Studies
  • Interleukin-6
  • Humans
 

Citation

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ICMJE
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Huffman, K. M., Pieper, C. F., Kraus, V. B., Kraus, W. E., Fillenbaum, G. G., & Cohen, H. J. (2011). Relations of a marker of endothelial activation (s-VCAM) to function and mortality in community-dwelling older adults. J Gerontol A Biol Sci Med Sci, 66(12), 1369–1375. https://doi.org/10.1093/gerona/glr121
Huffman, Kim M., Carl F. Pieper, Virginia B. Kraus, William E. Kraus, Gerda G. Fillenbaum, and Harvey J. Cohen. “Relations of a marker of endothelial activation (s-VCAM) to function and mortality in community-dwelling older adults.J Gerontol A Biol Sci Med Sci 66, no. 12 (December 2011): 1369–75. https://doi.org/10.1093/gerona/glr121.
Huffman KM, Pieper CF, Kraus VB, Kraus WE, Fillenbaum GG, Cohen HJ. Relations of a marker of endothelial activation (s-VCAM) to function and mortality in community-dwelling older adults. J Gerontol A Biol Sci Med Sci. 2011 Dec;66(12):1369–75.
Huffman, Kim M., et al. “Relations of a marker of endothelial activation (s-VCAM) to function and mortality in community-dwelling older adults.J Gerontol A Biol Sci Med Sci, vol. 66, no. 12, Dec. 2011, pp. 1369–75. Pubmed, doi:10.1093/gerona/glr121.
Huffman KM, Pieper CF, Kraus VB, Kraus WE, Fillenbaum GG, Cohen HJ. Relations of a marker of endothelial activation (s-VCAM) to function and mortality in community-dwelling older adults. J Gerontol A Biol Sci Med Sci. 2011 Dec;66(12):1369–1375.
Journal cover image

Published In

J Gerontol A Biol Sci Med Sci

DOI

EISSN

1758-535X

Publication Date

December 2011

Volume

66

Issue

12

Start / End Page

1369 / 1375

Location

United States

Related Subject Headings

  • Vascular Cell Adhesion Molecule-1
  • Solubility
  • Residence Characteristics
  • North Carolina
  • Multivariate Analysis
  • Mortality
  • Male
  • Longitudinal Studies
  • Interleukin-6
  • Humans