Urinary F2-isoprostanes as a biomarker of reduced risk of type 2 diabetes.

Published

Journal Article

We have previously reported evidence of an inverse association between a urinary F(2)-isoprostane and type 2 diabetes risk in a pilot case-control study nested within the Insulin Resistance Atherosclerosis Study (IRAS). Here, we report the results from the study extended to the entire IRAS cohort.This prospective study included 138 incident type 2 diabetes case and 714 noncase subjects. Four F(2)-isoprostanes (iPF2α-III; 2,3-dinor-iPF2α-III; iPF2α-VI; and 8,12-iso-iPF2α-VI) were assayed in baseline urine samples using liquid chromatography-tandem mass spectrometry.Three F(2)-isoprostanes showed significant inverse associations with type 2 diabetes risk: the adjusted odds ratios were 0.52 (95% CI 0.39-0.67), 0.56 (0.42-0.73), 0.62 (0.48-0.79), and 0.91 (0.72-1.12) for iPF2α-III; 2,3-dinor-iPF2α-III; iPF2α-VI; and 8,12-iso-iPF2α-VI, respectively.Our findings indicate that urinary F(2)-isoprostanes are inversely associated with type 2 diabetes risk beyond the traditional risk factors and may be useful in identifying high-risk populations.

Full Text

Duke Authors

Cited Authors

  • Il'yasova, D; Spasojevic, I; Base, K; Zhang, H; Wang, F; Young, SP; Millington, DS; D'Agostino, RB; Wagenknecht, LE

Published Date

  • January 2012

Published In

Volume / Issue

  • 35 / 1

Start / End Page

  • 173 - 174

PubMed ID

  • 22100959

Pubmed Central ID

  • 22100959

Electronic International Standard Serial Number (EISSN)

  • 1935-5548

International Standard Serial Number (ISSN)

  • 0149-5992

Digital Object Identifier (DOI)

  • 10.2337/dc11-1502

Language

  • eng