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Thermospray liquid chromatography/mass spectrometry for the analysis of L-carnitine and its short-chain acyl derivatives.

Publication ,  Journal Article
Yergey, AL; Liberato, DJ; Millington, DS
Published in: Anal Biochem
June 1984

A method utilizing thermospray high-performance liquid chromatography/mass spectrometry for the separation and direct analysis of carnitine, acetylcarnitine, and propionylcarnitine is described. On-column analysis of mixtures of the acylcarnitines with their corresponding stable, isotope-labeled analogs at nanomolar concentrations has indicated that isotope dilution assays can be applied towards the analysis of carnitine and short-chain acylcarnitines present in biological samples.

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Published In

Anal Biochem

DOI

ISSN

0003-2697

Publication Date

June 1984

Volume

139

Issue

2

Start / End Page

278 / 283

Location

United States

Related Subject Headings

  • Mass Spectrometry
  • Hot Temperature
  • Chromatography, High Pressure Liquid
  • Carnitine
  • Biochemistry & Molecular Biology
  • Acetylcarnitine
  • 3401 Analytical chemistry
  • 3101 Biochemistry and cell biology
  • 0601 Biochemistry and Cell Biology
  • 0399 Other Chemical Sciences
 

Citation

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Yergey, A. L., Liberato, D. J., & Millington, D. S. (1984). Thermospray liquid chromatography/mass spectrometry for the analysis of L-carnitine and its short-chain acyl derivatives. Anal Biochem, 139(2), 278–283. https://doi.org/10.1016/0003-2697(84)90003-4
Yergey, A. L., D. J. Liberato, and D. S. Millington. “Thermospray liquid chromatography/mass spectrometry for the analysis of L-carnitine and its short-chain acyl derivatives.Anal Biochem 139, no. 2 (June 1984): 278–83. https://doi.org/10.1016/0003-2697(84)90003-4.
Yergey, A. L., et al. “Thermospray liquid chromatography/mass spectrometry for the analysis of L-carnitine and its short-chain acyl derivatives.Anal Biochem, vol. 139, no. 2, June 1984, pp. 278–83. Pubmed, doi:10.1016/0003-2697(84)90003-4.
Journal cover image

Published In

Anal Biochem

DOI

ISSN

0003-2697

Publication Date

June 1984

Volume

139

Issue

2

Start / End Page

278 / 283

Location

United States

Related Subject Headings

  • Mass Spectrometry
  • Hot Temperature
  • Chromatography, High Pressure Liquid
  • Carnitine
  • Biochemistry & Molecular Biology
  • Acetylcarnitine
  • 3401 Analytical chemistry
  • 3101 Biochemistry and cell biology
  • 0601 Biochemistry and Cell Biology
  • 0399 Other Chemical Sciences